Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway

WuW.; YuX.; LuoX.-P.; YangS.-H.; ZhengD.

首页> 外文期刊>Behavioural Brain Research: An International Journal >Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway

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Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway

机译：川methyl嗪通过逆转cAMP / PKA / CREB途径防止东pol碱诱导的大鼠记忆力减退

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Tetramethylpyrazine is used in the treatment of many neurological diseases because of its neuroprotective effect. Here, we demonstrate that administration of tetramethylpyrazine effectively reverses memory deficits induced by scopolamine. Moreover, tetramethylpyrazine preserves postsynaptic protein synthesis and restores cAMP/PKA/CREB pathway signaling deficits. Our study not only explores the actions of tetramethylpyrazine on synapses, but also provides novel evidence for the possible therapeutic use of tetramethylpyrazine in dementia.

机译：川methyl嗪因其神经保护作用而被用于治疗许多神经系统疾病。在这里，我们证明四甲基吡嗪的管理有效地扭转了东pol碱诱导的记忆缺陷。此外，四甲基吡嗪保留了突触后蛋白的合成并恢复了cAMP / PKA / CREB信号通路的缺陷。我们的研究不仅探讨了川methyl嗪对突触的作用，而且为川methyl嗪在痴呆中的可能治疗用途提供了新的证据。

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《Behavioural Brain Research: An International Journal》 |2013年第null期|共5页
作者
WuW.; YuX.; LuoX.-P.; YangS.-H.; ZhengD.;
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正文语种 eng
中图分类医学心理学、病理心理学;
关键词
Memory; Scopolamine; Synapse; Tetramethylpyrazine;

机译：记忆;东pol碱;突触;四甲基吡嗪;

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1. Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway [J] . WuW., YuX., LuoX.-P., Behavioural Brain Research: An International Journal . 2013,第Null期

机译：川methyl嗪通过逆转cAMP / PKA / CREB途径防止东pol碱诱导的大鼠记忆力减退
2. PKA-CREB-BDNF signaling pathway mediates propofol-induced long-term learning and memory impairment in hippocampus of rats [J] . Zhong Yu, Chen Jing, Li Li, Brain research . 2018,第期

机译：PKA-CREB-BDNF信号通路介导异丙酚诱导的大鼠海马的长期学习和记忆障碍
3. Dexmedetomidine protects rats from postoperative cognitive dysfunction via regulating the GABA(B)R-mediated cAMP-PKA-CREB signaling pathway [J] . Zhu Yun-Sheng, Xiong Ying-Fen, Luo Fo-Quan, Neuropathology: official journal of the Japanese Society of Neuropathology . 2019,第1期

机译：Dexmedetomidine通过调节GABA（B）介导的Camp-PKA-Creb信号通路来保护大鼠从术后认知功能障碍免受术后认知功能障碍
4. PingYu Capsule Activates cAMP/PKA/CREB Signaling Pathway in Rat Hippocampus: A Possible Mechanism for Antidepressant-Like Effect [C] . Jun-Sheng Tian, Yuan-Lu Cui, Zuo-Guang Zhang Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009 . 2009

机译：平鱼胶囊激活大鼠海马中的cAMP / PKA / CREB信号通路：一种抗抑郁样作用的可能机制
5. Impairment of cAMP response element binding protein (CREB) signaling in Alzheimer's disease: Implication for neurodegeneration. [D] . He, Yang. 2006

机译：阿尔茨海默氏病中cAMP反应元件结合蛋白（CREB）信号传导的受损：对神经变性的影响。
6. cAMP/PKA-CREB-BDNF signaling pathway in hippocampus mediates cyclooxygenase 2-induced learning/memory deficits of rats subjected to chronic unpredictable mild stress [O] . Ying Luo, Shengnan Kuang, Huan Li, 2017

机译：海马中的cAMP / PKA-CREB-BDNF信号传导通路介导环氧合酶2诱导的慢性不可预测轻度应激大鼠的学习/记忆缺陷
7. Long-term Surgical and Chemical Castration Deteriorates Memory Function Through Downregulation of PKA/CREB/BDNF and c-Raf/MEK/ERK Pathways in Hippocampus [O] . Mal-Soon Shin, Tae-Won Kim, Sang-Seo Park, 2019

机译：长期外科和化学阉割通过在海马的PKA / CREB / BDNF和C-RAF / MEK / ERK途径的下调恶化了记忆功能

Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway

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