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首页> 外文期刊>Behavioural pharmacology >Lack of sex-related differences in the prevention by baclofen of the morphine withdrawal syndrome in mice.
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Lack of sex-related differences in the prevention by baclofen of the morphine withdrawal syndrome in mice.

机译：巴氯芬对小鼠吗啡戒断综合征的预防缺乏性别相关的差异。

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摘要

In previous studies we have demonstrated a possible interaction between the GABAergic and opioid systems involved in the antinociceptive effect of the GABA(B) agonist, baclofen (BAC). On the other hand, sex differences have been observed for the antinociceptive effect of morphine (MOR). In the present study, we analyzed sex-related differences in the MOR abstinence syndrome and its prevention with BAC. Prepubertal male and female Swiss-Webster albino mice (27-33 g) were rendered dependent by intraperitoneal (i.p.) injection of MOR (2, 4 and 8 mg/kg), twice daily for 9 days. On the tenth day the dependent animals were divided into two groups: one received naloxone (NAL) (6 mg/kg, i.p.) 60 min after the last dose of MOR, to precipitate the abstinence syndrome; the other group received BAC (2 mg/kg, i.p.) followed by NAL (6 mg/kg, i.p.), injected 30 and 60 min after the last dose of MOR, respectively. Behavioral signs were recorded in the open field for 30 min. Although there were sex differences in the MOR withdrawal syndrome, we found a lack of sex differences in the prevention of the MOR abstinence syndrome by BAC.
机译：在以前的研究中，我们证明了参与GABA（B）激动剂巴氯芬（BAC）的抗伤害感受作用的GABA能和阿片类药物系统之间可能存在相互作用。另一方面，已观察到性别差异对吗啡（MOR）的镇痛作用。在本研究中，我们分析了MOR节欲综合征与BAC预防中的性别相关差异。每天两次腹膜内（i.p.）注射MOR（2、4和8 mg / kg）使青春期前的雄性和雌性Swiss-Webster白化病小鼠（27-33 g）依赖，每天两次，共9天。在第10天，将依赖的动物分为两组：一组在最后一次MOR后60分钟接受纳洛酮（NAL）（6mg / kg，腹膜内）以引起禁欲综合征。另一组分别接受BAC（2 mg / kg，i.p.）和NAL（6 mg / kg，i.p.），分别在末次MOR注射后30分钟和60分钟注射。在空旷的地方记录30分钟的行为迹象。尽管在MOR戒断综合征中存在性别差异，但我们发现在BAC预防MOR戒断综合征中缺乏性别差异。

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