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首页> 外文期刊>Otology and neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology >A Gerbil Model of Sloping Sensorineural Hearing Loss
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A Gerbil Model of Sloping Sensorineural Hearing Loss

机译：倾斜感官听力损失的沙鼠模型

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Objective: The goal of the overall project is to develop knowledge about cochlear physiology during cochlear implantation and develop procedures for assessing its status during hearing preservation surgery. As a step toward this goal, for this study, we established an animal model of sloping high frequency sensorineural hearing loss that mimics the hearing condition of candidates for combined electric-acoustic stimulation. Methods: Mongolian gerbils were exposed to band-pass noise using various cutoff frequencies, intensities, exposure times, and survival times. Hearing loss was assessed in far-field recording using preexposure and postexposure auditory brainstem responses (ABRs), and in acute, near-field recordings of the cochlear microphonic and compound action potential from an electrode on the round window. Anatomic loss of hair cells was assessed from dissections.Results: Postexposure ABRs and near-field recordings from the round window revealed sensorineural hearing loss that varied with the overall noise exposure. Loss of hair cells ranged from relatively sparse to large areas of complete absence depending on the noise exposure. Cases with high intensity (120 dB SPL) and long exposure times (3 h) showed sloping patterns of hearing loss with profound high-frequency loss and mild-to-moderate low-frequency loss. These cases showed complete loss of hair cells in the basal cochlea and preserved hair cells in the apical cochlea. The frequencies comprising the slope in the ABRs and the location of the transition zone between preserved and lost hair cells varied according to the cutoff frequency used. Conclusion: We were able to reliably induce sensorineural hearing loss and loss of hair cells in the gerbil that is comparable to candidates for hearing preservation surgery. This model can be used to evaluate the effects of electrode introduction in a system with a hearing condition similar to that in cases of hearing preservation operations.
机译：目的：整个项目的目标是在人工耳蜗期间发展有关人工耳蜗生理的知识，并制定了在听力保存手术期间评估其状态的程序。作为朝着这一目标迈出的一步，我们建立了一种动物模型，该模型倾斜了高频感官听力损失，模仿了候选人的听力状况，以进行电声刺激。方法：使用各种截止频率，强度，暴露时间和生存时间，将蒙古的沙鼠暴露于带通噪声。使用预触发和暴露后听觉脑干反应（ABR）以及急性的，近场记录了对耳蜗微音和复合动作电位的急性记录，从圆形窗户上的电极上评估了听力损失。从解剖中评估了毛细胞的解剖学丧失。分析：暴露后ABR和圆形窗口中的近场记录显示，感觉到听力损失，随着整体噪声暴露而异。毛细胞的丧失范围从相对稀疏到完全缺席的大面积，具体取决于噪声的暴露。高强度（120 dB SPL）和长时间暴露时间（3小时）的病例显示出听力丧失的倾斜模式，高频丧失和轻度到中度的低频损失。这些病例表明，基础耳蜗中毛细胞完全丧失，并保留了顶端耳蜗中的毛细胞。频率包括ABR中的斜率以及保留和丢失的毛细胞之间的过渡区的位置根据所使用的截止频率而变化。结论：我们能够可靠地诱导Gerbil中的感觉性听力丧失和毛细胞的丧失，这与候选人的听力保存手术相当。该模型可用于评估与听力保存操作相似的听力条件系统中电极引入的效果。

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