Resiquimod: a new immune response modifier with potential as a vaccine adjuvant for Th1 immune responses.

Wu JJ; Huang DB; Tyring SK

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Resiquimod: a new immune response modifier with potential as a vaccine adjuvant for Th1 immune responses.

机译：Resiquimod：一种新的免疫应答修饰剂，具有作为Th1免疫应答的疫苗佐剂的潜力。

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Genital herpes is one of the most common sexually transmitted diseases worldwide. Currently, there are three FDA-approved nucleoside analogs and other therapies such as foscarnet and cidofovir used to treat genital herpes. Resiquimod, the latest immune response modifier (IRM), has shown in vivo evidence of efficacy against herpes simplex virus (HSV) type 2. The first clinical trial involving resiquimod demonstrated that it reduced the recurrence rate of genital herpes, but phase III trials were suspended due to lack of efficacy. Resiquimod shows promise for other viral infections and as a vaccine adjuvant.

机译：生殖器疱疹是全世界最常见的性传播疾病之一。目前，有3种FDA批准的核苷类似物和其他疗法（例如膦甲酸酯和西多福韦）用于治疗生殖器疱疹。最新的免疫反应调节剂（IRM）雷西莫德（Resiquimod）已显示出抗2型单纯疱疹病毒（HSV）功效的体内证据。第一项涉及雷西莫德的临床试验表明，它降低了生殖器疱疹的复发率，但III期试验是因缺乏疗效而被停赛。雷西莫德显示出有望用于其他病毒感染和作为疫苗佐剂。

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《Antiviral Research》 |2004年第2期|共5页
作者
Wu JJ; Huang DB; Tyring SK;
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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
Immune response; vaccine adjuvant; genital herpes; resiquimod;

机译：免疫反应;疫苗佐剂;生殖器疱疹;瑞西莫德;

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1. Resiquimod: a new immune response modifier with potential as a vaccine adjuvant for Th1 immune responses. [J] . Wu JJ, Huang DB, Tyring SK Antiviral Research . 2004,第2期

机译：Resiquimod：一种新的免疫应答修饰剂，具有作为Th1免疫应答的疫苗佐剂的潜力。
2. Platycodin D2 is a potential less hemolytic saponin adjuvant eliciting Th1 and Th2 immune responses. [J] . Xie Y, Deng W, Sun H, International immunopharmacology . 2008,第8期

机译：Platycodin D2是一种潜在的溶血性较低的皂苷佐剂，可引发Th1和Th2免疫反应。
3. Skin delivery of a hybrid liposome/ISCOM vaccine implicates a role for adjuvants in rapid modulation of inflammatory cells involved in innate immunity before the enhancement of adaptive immune responses. [J] . Chin J, San-Gil F Immunology and Cell Biology . 1998,第3期

机译：混合脂质体/ ISCOM疫苗的皮肤输送牵涉佐剂在增强适应性免疫应答之前快速调节先天免疫所涉及的炎症细胞。
4. Adjuvant Conjugated Microparticles for Vaccine Delivery: A Robust Method to Promote Immune Response [C] . Kirsten Brink, Michael V. Pishko Society for Biomaterials annual meeting and exposition . 2015

机译：佐剂共轭微粒用于疫苗递送：增强免疫反应的鲁棒方法
5. HIV-1 immunity: Innate immune correlates and vaccine responses. [D] . Pine, Samuel O'Neill. 2009

机译：HIV-1免疫：先天免疫相关性和疫苗反应。
6. The PorB porin from commensal Neisseria lactamica induces Th1 and Th2 immune responses to ovalbumin in mice and is a potential immune adjuvant [O] . Xiuping Liu, Lee M. Wetzler, Paola Massari -1

机译：乳酸共生奈瑟氏球菌的PorB孔蛋白可诱导小鼠对卵白蛋白的Th1和Th2免疫反应是一种潜在的免疫佐剂
7. Immunization of aged pigs with attenuated pseudorabies virus vaccine combined with CpG oligodeoxynucleotide restores defective Th1 immune responses. [O] . Feiping Ming, Jun Yang, Pinpin Chu, 2013

机译：用减毒伪狂犬病毒疫苗与CpG寡脱氧核苷酸结合免疫老年猪可恢复有缺陷的Th1免疫应答。
8. Comprehensive Profiling of Immune Responses in MARV Survivors Demonstrates Robust Th1-Skewing with Short Lived Neutralizing Antibody Responses. [R] . Stonier, S. W., Herbert, A. S., Kuehne, A. I., 2017

机译：maRV幸存者免疫反应的综合分析证明了具有短暂中和抗体反应的强烈Th1-skewing。

Resiquimod: a new immune response modifier with potential as a vaccine adjuvant for Th1 immune responses.

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