Knocking off their Sox: Lineage-specific repression by Polycomb in epidermal stem cells

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Knocking off their Sox: Lineage-specific repression by Polycomb in epidermal stem cells

机译：敲掉袜:Lineage-specificPolycomb镇压的表皮干细胞

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A recent publication in The EMBO Journal (Bardot et al, 2013) provides novel insights into lineage specification during the development of the mouse skin. Ezhkova and colleagues demonstrate that Ezh1 and Ezh2, core enzymes of the Polycomb Repressive Complex (PRC), restrict differentiation of Merkel cells, a specialized population of mechanosensory cells by directly repressing the cell fate determinant transcription factor (TF) Sox2 in epidermal progenitors.

机译：最近发表在EMBO杂志(芭铎等,2013)提供了新颖的见解血统规范在鼠标的发展的皮肤。Polycomb Ezh1 Ezh2,核心酶压抑的复杂(中华人民共和国),限制默克尔细胞分化,专业人口mechanosensory细胞通过直接抑制细胞命运的决定因素转录因子(TF) Sox2在表皮祖细胞。

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来源
《EMBO Journal》 |2013年第14期|1970-1971|共2页
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作者单位

Molecular Biology and Genetics, Cornell University, Ithaca, NY, United States;

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正文语种英语
中图分类分子生物学;分子生物学;
关键词
Chromatin Remodeling Factor; Merkel Cells; epidermal stem cellsulfur monoxideStem CellsEpidermis;

机译：染色质重塑因子;默克尔细胞,表皮茎cellsulfur monoxideStem CellsEpidermis;

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1. Epigenetic Repression of SATB1 by Polycomb Group Protein EZH2 in Epithelial Cells [J] . Lei Li, Lu Lu, Xiang Lu, 中国医学科学杂志：英文版 . 2010,第004期
2. Epigenetic Repression of SATB1 by Polycomb Group Protein EZH2 in Epithelial Cells [J] . Lei Li, Lu Lu, Xiang Lü, 中国医学科学杂志（英文版） . 2010,第004期
3. Epidermal growth factor enhances chemosensitivityof colon cancer by inducing cancer stem cells toenter the cell cycle [J] . YOU Zou Xiaolan Li Deding Tao Junbo Hu Jianping Gong 肿瘤学与转化医学（英文） . 2017,第002期
4. Epidermal growth factor enhances chemosensitivity of colon cancer by inducing cancer stem cells to enter the cell cycle [J] . You Zou, Xiaolan Li, Deding Tao, 中德临床肿瘤学杂志（英文版） . 2017,第002期
5. Enrichment of putative human epidermal stem cells based on cell size and collagen type IV adhesiveness [J] . Juxue Li, Enkui Duan, Chenglin Miao, 细胞研究（英文版） . 2008,第003期
6. AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2 [J] . Hana Kim, Joomyeong Kim, Keunsoo Kang Nucleic acids research . 2009,第9期

机译：AEBP2作为Polycomb Repression Complex PRC2的潜在靶向蛋白
7. AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2 [J] . Hana Kim, Joomyeong Kim, Keunsoo Kang Nucleic acids research . 2009,第9期

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8. AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2 [J] . Kim H, Kang K, Kim J Nucleic Acids Research . 2009,第9期

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9. Advances in STEM-CELL. A Free Software for TEM and STEM Analysis and Simulations: Probe Deconvolution in STEM-HAADF [C] . V.Grillo International Metallographic Society Annual meeting;Microscopy Society of America Annual Meeting;Microanalysis Society Annual meeting . 2011

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10. Th22 cells control colon tumorigenesis through STAT3 and Polycomb Repression complex 2 signaling [O] . Danfeng Sun, Yanwei Lin, Jie Hong, 2016

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11. AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2 [O] . Kim, Hana, Kang, Keunsoo, Kim, Joomyeong 2009

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Knocking off their Sox: Lineage-specific repression by Polycomb in epidermal stem cells

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