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首页> 外文期刊>Angiology: the Journal of Vascular Diseases >Evaluation of enalapril+losartan treatment with cardiopulmonary exercise test in patients with left ventricular dysfunction.
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Evaluation of enalapril+losartan treatment with cardiopulmonary exercise test in patients with left ventricular dysfunction.

机译：左心功能不全患者通过心肺运动试验评估依那普利+氯沙坦的治疗效果。

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The aim of this study was to evaluate the effects of the combination of enalapril and losartan in patients with left ventricular systolic dysfunction by means of cardiopulmonary exercise test (CPET). Patients with left-ventricular systolic dysfunction and ejection fractions of 40% or less were included to the study. All patients were under the treatment of enalapril 20 mg once daily. The study group consisted of 20 patients (18 men, 2 women; mean age +/- standard deviation: 62.4 +/-6.5 years) and the comparison group consisted of 10 (8 men, 2 women; mean age 59.3 +/-11.9 years). The dose of 50 mg of losartan once daily was given additionally to the study patients. Breath-by-breath CPET was performed before administration of losartan and then 6-8 weeks later in the study group and 2 times with an interval of 6-8 weeks in the control group without any change in the treatment protocol. In the study group the average exercise times were 361 +/-192 and 454 +/-205 seconds (p = 0.001) before and after the study. Peak oxygen consumption ( VO2) values were 1,209 +/-366 and 1,284 +/-398 mL/minute before and after the study (p = 0.01). Anaerobic threshold VO2 values were 785 +/-187 and 855 +/-217 mL/minute before and after the study, respectively (p = 0.01). Peak heart rates (HR) were 141 +/-28 and 143 +/-22/minute (p = 0.35); peak VO2/HR values were 9.02 +/-3.1 and 9.3 +/-3 mL/minute (p = 0.4) before and after the study, respectively. On the other hand, in the control group, average exercise times were 556 +/-250 and 528 +/-251 seconds (p = 0.8); peak VO2 values were 1,502 +/-537 and 1,450 +/-501 mL/minute (p = 0.2); and anaerobic threshold VO2 values were 1,005 +/-338 and 975 +/-319 mL/min (p 0.7), before and after the study respectively. At the highest comparable exercise stage for both tests in the study group the expired volume/oxygen consumption ( VE/ VO2) ratio declined from 35.1 +/-6.2 to 32.4 +/-5.6 (p = 0.007). VE values declined from 37.5 +/-10.9 to 33.9 +/-10.1 L (p = 0.02); heart rate declined from 140 +/-27 to 132 +/-21/minute (p = 0.02). No significant change was observed in the mentioned values for the control group. Addition of losartan to the standard therapy in patients with left ventricular systolic dysfunction improved exercise capacity and caused lower heart rate and ventilation requirements for the same exercise level.
机译：这项研究的目的是通过心肺运动试验（CPET）评估依那普利和氯沙坦联用对左室收缩功能不全患者的影响。左室收缩功能不全且射血分数小于或等于40％的患者均纳入研究。所有患者每天接受一次依那普利20 mg治疗。研究组包括20名患者（18名男性，2名女性;平均年龄+/-标准差：62.4 +/- 6.5岁），而对照组则包括10名（8名男性，2名女性;平均年龄59.3 +/- 11.9岁）年份）。每天一次给研究患者服用50毫克氯沙坦的剂量。在服用氯沙坦之前进行逐次呼吸CPET，然后在研究组中进行6-8周，在对照组中进行2次，间隔6-8周，而治疗方案没有任何变化。在研究组中，研究前后平均运动时间为361 +/- 192秒和454 +/- 205秒（p = 0.001）。研究之前和之后的峰值耗氧量（VO2）值为1,209 +/- 366和1,284 +/- 398 mL / min（p = 0.01）。研究之前和之后，厌氧VO2阈值分别为785 +/- 187和855 +/- 217 mL / min（p = 0.01）。最高心率（HR）为141 +/- 28 /分钟和143 +/- 22 /分钟（p = 0.35）;在研究之前和之后，VO2 / HR峰值分别为9.02 +/- 3.1和9.3 +/- 3 mL / min（p = 0.4）。另一方面，对照组的平均运动时间为556 +/- 250秒和528 +/- 251秒（p = 0.8）; VO2峰值为1,502 +/- 537和1,450 +/- 501 mL /分钟（p = 0.2）;在研究之前和之后，无氧VO2阈值分别为1,005 +/- 338 mL / min和975 +/- 319 mL / min（p 0.7）。在研究组中两个测试的最高可比运动阶段，呼出气量/耗氧量（VE / VO2）比从35.1 +/- 6.2下降至32.4 +/- 5.6（p = 0.007）。 VE值从37.5 +/- 10.9升降至33.9 +/- 10.1升（p = 0.02）;心率从140 +/- 27降低到132 +/- 21 /分钟（p = 0.02）。对照组的上述数值未见明显变化。对于左心室收缩功能障碍的患者，在标准疗法中加用氯沙坦可改善运动能力，并在相同运动水平下降低心率和通气量。

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