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Novel group of podovirus infecting the marine bacterium Alteromonas macleodii

机译：小说群podovirus感染海洋细菌Alteromonas macleodii

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摘要

Four novel, closely related podoviruses, which displayed lytic activity against the gamma-proteobacterium Alteromonas macleodii, have been isolated and sequenced. Alterophages AltAD45-P1 to P4 were obtained from water recovered near a fish farm in theMediterranean Sea. Their morphology indicates that they belong to the Podoviridae. Their linear and dsDNA genomes are 100–104 kb in size, remarkably larger than any other described podovirus. The four AltAD45-phages share 99% nucleotide sequence identity over 97% of their ORFs, although an insertion was found in AltAD45-P1 and P2 and some regions were slightly more divergent. Despite the high overall sequence similarity among these four phages, the group with the insertion and the group without it, have different host ranges against the A. macleodii strains tested. The AltAD45-P1 to P4 phages have genes for DNA replication and transcription as well as structural genes, which are similar to the N4-like Podoviridae genus that is widespread in proteobacteria. However, in terms of their genomic structure, AltAD45-P1 to P4 differ from that of the N4-like phages. Some distinguishing features include the lack of a large virion encapsidated RNA polymerase gene, very well conserved among all the previously described N4-like phages, a single-stranded DNA binding protein and different tail protein genes. We conclude that the AltAD45 phages characterized in this study constitute a new genus within the Podoviridae.
机译：四个小说,podoviruses密切相关,显示对溶解性活动gamma-proteobacterium Alteromonas macleodii,被隔离和测序。AltAD45-P1 P4从水中获得恢复在theMediterranean一个养鱼场附近海中。Podoviridae。基因组大小100 - 104 kb,非常大比其他任何podovirus描述。AltAD45-phages分享99%的核苷酸序列身份超过97%的羊痘疮,尽管一个插入在AltAD45-P1和P2和一些被发现地区稍微发散。这四个高整体序列相似性噬菌体,插入和没有它,有不同的宿主范围对a macleodii压力测试。AltAD45-P1 P4噬菌体基因DNA复制和转录结构基因,类似N4-like Podoviridae属中普遍存在的变形菌门。基因组结构,AltAD45-P1 P4不同N4-like噬菌体。功能包括缺乏大量的病毒粒子使壳体化RNA聚合酶基因,很好在所有前面描述的守恒N4-like噬菌体单链DNA结合蛋白质和不同尾蛋白基因。得出结论:AltAD45噬菌体的特点本研究构成中的一个新的属

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