...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Behavioural pharmacology >Naloxone-precipitated withdrawal causes an increase in impulsivity in morphine-dependent rats
【24h】

Naloxone-precipitated withdrawal causes an increase in impulsivity in morphine-dependent rats

机译：纳洛酮沉淀的戒断导致吗啡依赖性大鼠的冲动增加

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Opiate dependence is associated with increased impulsivity in both humans and animals. Although the state of withdrawal appears to contribute to this effect, a causal relationship has not been shown. Here, we test whether precipitating withdrawal in morphine-dependent rats through naloxone can cause increased impulsivity. Rats were trained on a delay discounting task and then randomly assigned to either a dependent group that received a nightly 30 mg/kg subcutaneous dose of morphine or a naive group that received nightly saline. Once dependence was established, 2-day test delay discounting curves were determined 1 h after three doses of naloxone (0, 0.25, 0.5 mg/kg). In dependent rats both doses of naloxone caused increased preference for the small reward at short delays. Naloxone had no effect on delay discounting in naive rats. We conclude that precipitating withdrawal in dependent rats can cause increased impulsivity. Behavioural Pharmacology 26:326-329 Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.
机译：阿片类药物依赖性与人和动物的冲动增加有关。尽管退出状态似乎有助于这种效果，但尚未显示因果关系。在这里，我们测试了吗啡依赖性大鼠通过纳洛酮促成戒断是否会引起冲动增加。对大鼠进行延迟打折任务训练，然后将其随机分配至接受每晚皮下注射30 mg / kg吗啡的依赖组或接受夜间生理盐水的幼稚组。建立依赖性后，在三剂纳洛酮（0、0.25、0.5 mg / kg）后1 h确定2天测试延迟贴现曲线。在成年大鼠中，两种剂量的纳洛酮都会导致对小剂量奖励的偏好在短时间内增加。纳洛酮对幼稚大鼠的延迟贴现没有影响。我们得出的结论是，在依赖大鼠中出现戒断可能会导致冲动增加。行为药理学26：326-329版权所有（C）2015 Wolters Kluwer Health，Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号