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首页> 外文期刊>Applied Microbiology and Biotechnology >Enantioselective reduction of 3,4-methylene-dioxyphenylacetone using Candida famata and Zygosaccharomyces rouxii
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Enantioselective reduction of 3,4-methylene-dioxyphenylacetone using Candida famata and Zygosaccharomyces rouxii

机译：使用Candida famata和Zygosaccharomyces rouxii对映体选择性还原3,4-亚甲基-二氧基苯丙酮

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In an effort to prepare 3,4-methylene-dioxyphenyl-(S)-isopropanol from 3,4-methylene-dioxyphenylacetone, an initial screen of microbes indicated that Candida famata could catalyze this reaction efficiently at low substrate concentration. A dilute, large-scale process was developed to provide experimental material for the chemical synthesis to be explored. However, the productivity number of this process [0.134 g product (g wet weight cells)-1 day-1 was too low to be practical. C. famata was also extremely sensitive to concentrations of both the ketone and the alcohol greater than 2 g/l. A more extensive screen of yeast and fungi revealed that Zygosaccharomyces rouxii was more tolerant to higher substrate concentrations and had a higher productivity number [0.8 g (g wet weight cells)-1 day-1]. These characteristics suggested that Z. rouxii could be used in a large-scale process at high substrate concentrations.
机译：为了从3,4-亚甲基-二氧基苯基丙酮制备3,4-亚甲基-二氧基苯基-（S）-异丙醇，微生物的初步筛选表明，念珠菌可以在低底物浓度下有效地催化该反应。开发了一种稀疏的大规模工艺，为要探索的化学合成提供实验材料。但是，该方法的生产率数[0.134g产物（g湿重池）-1天-1]太低而不能实用。此外，C。famata对大于2 g / l的酮和醇的浓度也极为敏感。酵母和真菌的更广泛筛选显示，鲁氏酵母对更高的底物浓度具有更高的耐受性，并具有更高的生产率数[0.8 g（g湿重细胞）-1 day-1]。这些特征表明鲁氏沼虾可以在高底物浓度下大规模应用。

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