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首页> 外文期刊>Applied Microbiology and Biotechnology >Antimicrobial peptides: an alternative for innovative medicines?
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Antimicrobial peptides: an alternative for innovative medicines?

机译：抗菌肽：创新药物的替代品？

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摘要

Antimicrobial peptides are small molecules with activity against bacteria, yeasts, fungi, viruses, bacteria, and even tumor cells that make these molecules attractive as therapeutic agents. Due to the alarming increase of antimicrobial resistance, interest in alternative antimicrobial agents has led to the exploitation of antimicrobial peptides, both synthetic and from natural sources. Thus, many peptide-based drugs are currently commercially available for the treatment of numerous ailments, such as hepatitis C, myeloma, skin infections, and diabetes. Initial barriers are being increasingly overcome with the development of cost-effective, more stable peptides. Herein, we review the available strategies for their synthesis, bioinformatics tools for the rational design of antimicrobial peptides with enhanced therapeutic indices, hurdles and shortcomings limiting the large-scale production of AMPs, as well as the challenges that the pharmaceutical industry faces on their use as therapeutic agents.
机译：抗菌肽是对细菌，酵母，真菌，病毒，细菌，甚至是肿瘤细胞具有活性的小分子，这些分子使它们成为治疗剂具有吸引力。由于令人惊奇的抗微生物剂增加，对替代抗微生物剂的兴趣导致对合成和天然来源的抗微生物肽的开发。因此，许多基于肽的药物目前可商购用于治疗多种疾病，例如丙型肝炎，骨髓瘤，皮肤感染和糖尿病。随着具有成本效益的，更稳定的肽的开发，越来越多的克服了最初的障碍。在本文中，我们回顾了其合成的可用策略，合理设计具有增强治疗指数的抗菌肽的生物信息学工具，限制大规模生产AMP的障碍和缺点，以及制药行业在使用它们方面面临的挑战作为治疗剂。

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