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When Myc's asleep, embryonic stem cells are dormant

机译:当Myc的睡着了,胚胎干细胞休眠

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摘要

Myc is one of the original reprogramming factors used to produce induced pluripotent stem cells. However, it is not necessary, instead its main role is to increase the efficiency of the reprogramming. The article by Scognamiglio etal (2016) helps clarify how. The authors show that Myc depletion leads to a reversible dormant state consistent with diapause. In this state, the cell sees its proliferation potential diminished but its pluripotency unchanged. The ability to coordinate the induction of this state should have important implications in cell differentiation.
机译:Myc是原重组因子之一用于产生诱导多能干细胞。然而,这并不是必须的,而不是其主要的作用是增加的效率重新编程。(2016)有助于阐明如何。Myc损耗导致可逆的休眠状态与滞育一致。看到其增殖潜力降低其多能性不变。协调这个状态的感应在细胞有重要意义吗分化。

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