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首页> 外文期刊>Applied Microbiology and Biotechnology >An update on microbial carotenoid production: application of recent metabolic engineering tools
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An update on microbial carotenoid production: application of recent metabolic engineering tools

机译：微生物类胡萝卜素生产的最新进展：最新代谢工程工具的应用

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摘要

Carotenoids are ubiquitous pigments synthesized by plants, fungi, algae, and bacteria. Industrially, carotenoids are used in pharmaceuticals, neutraceuticals, and animal feed additives, as well as colorants in cosmetics and foods. Scientific interest in dietary carotenoids has increased in recent years because of their beneficial effects on human health, such as lowering the risk of cancer and enhancement of immune system function, which are attributed to their antioxidant potential. The availability of carotenoid genes from carotenogenic microbes has made possible the synthesis of carotenoids in non-carotenogenic microbes. The increasing interest in microbial sources of carotenoid is related to consumer preferences for natural additives and the potential cost effectiveness of creating carotenoids via microbial biotechnology. In this review, we will describe the recent progress made in metabolic engineering of non-carotenogenic microorganisms with particular focus on the potential of Escherichia coli for improved carotenoid productivity.
机译：类胡萝卜素是植物，真菌，藻类和细菌合成的普遍存在的色素。在工业上，类胡萝卜素用于药物，神经营养药物和动物饲料添加剂，以及化妆品和食品中的着色剂。近年来，由于对类胡萝卜素对人体健康的有益影响，例如对降低癌症风险和增强免疫系统功能的有益作用，人们对饮食类胡萝卜素的科学兴趣日益增强，这归因于其抗氧化潜力。来自类胡萝卜素微生物的类胡萝卜素基因的可用性使非类胡萝卜素微生物中类胡萝卜素的合成成为可能。消费者对类胡萝卜素的微生物来源的兴趣与日俱增，这与消费者对天然添加剂的偏爱以及通过微生物生物技术生产类胡萝卜素的潜在成本效益有关。在这篇综述中，我们将描述非类胡萝卜素微生物代谢工程方面的最新进展，特别关注大肠杆菌改善类胡萝卜素生产力的潜力。

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