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首页> 外文期刊>Applied Microbiology and Biotechnology >The influence of beta-cyclodextrin on the kinetics of 1-en-dehydrogenation of 6 alpha-methylhydrocortisone by Arthrobacter globiformis cells
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The influence of beta-cyclodextrin on the kinetics of 1-en-dehydrogenation of 6 alpha-methylhydrocortisone by Arthrobacter globiformis cells

机译：β-环糊精对球形节杆菌细胞对6α-甲基氢化可的松进行1-en脱氢动力学的影响

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摘要

beta-Cyclodextrin changes the kinetic peculiarities of microbial 1-en-dehydrogenation of 6 alpha-methylhydrocortisone: the reaction rate, degree of conversion and respiratory-chain activity are increased. Respiratory-chain activity in the presence of beta-cyclodextrin is increased both in the presence and in the absence of 6 alpha-methylhydrocortisone. A mathematical model is proposed to describe the kinetics of the process. This model suggests the formation of different multi-component complexes consisting of inclusion complexes and the functional unit involving the enzyme and the respiratory chain. All the parameters of the model were estimated by data fitting. In the model framework the formation of multi-component complexes leads to an increase of the maximal reaction rate and to a decrease of substrate inhibition. An approach is suggested for optimisation of 6 alpha-methylhydrocortisone 1-en-dehydrogenation in the presence of beta-cyclodextrin. The optimal concentrations of 6 alpha-methylhydrocortisone and beta-cyclodextrin have been calculated.
机译：β-环糊精改变了6α-甲基氢可的松对微生物1-烯脱氢的动力学特性：反应速率，转化度和呼吸链活性增加。在存在和不存在6α-甲基氢可的松的情况下，在存在β-环糊精的情况下，呼吸链的活性都会增加。提出了描述该过程动力学的数学模型。该模型表明形成了由包含物复合物和涉及酶和呼吸链的功能单元组成的不同的多组分复合物。通过数据拟合估计模型的所有参数。在模型框架中，多组分复合物的形成导致最大反应速率的增加和底物抑制的降低。建议一种在β-环糊精存在下优化6-α-甲基氢化可的松1-en-脱氢的方法。已经计算出6α-甲基氢可的松和β-环糊精的最佳浓度。

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