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What is uremia? Retention versus oxidation.

机译：什么是尿毒症？保留与氧化。

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摘要

The uremic syndrome is characterized by the retention of a host of compounds which in healthy subjects are secreted into the urine by the healthy kidneys. These compounds disturb many physiologic functions, resulting in toxicity. However, many of the retained compounds as well as many of the pathophysiologic actions of the known retention solutes remain unknown. In this publication, we review recent information on uremic toxicity. Especially the difficulty to remove compounds, such as protein-bound compounds and larger molecules, seems to play a crucial role. New strategies enhancing their removal might be highly useful. Part of the retained compounds are the result of oxidative processes due to the inflammatory status of uremic patients; however, other compounds are not, and even the concentration of oxidative compounds will be further increased by disturbances of urinary clearance.
机译：尿毒症综合征的特征在于保留了许多化合物，这些化合物在健康受试者中被健康肾脏分泌到尿液中。这些化合物干扰许多生理功能，导致毒性。然而，许多保留的化合物以及已知保留溶质的许多病理生理作用仍然未知。在本出版物中，我们回顾了有关尿毒症毒性的最新信息。尤其是去除化合物（如结合蛋白质的化合物和大分子）的困难似乎起着至关重要的作用。增强清除效果的新策略可能非常有用。由于尿毒症患者的炎症状态，部分保留的化合物是氧化过程的结果;但是，其他化合物却没有，甚至氧化性化合物的浓度也会因排尿障碍而进一步增加。

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