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首页> 外文期刊>Chemical Engineering Research & Design: Transactions of the Institution of Chemical Engineers >Design,scale up and safe piloting of thymol hydrogenation and menthol racemisation
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Design,scale up and safe piloting of thymol hydrogenation and menthol racemisation

机译：设计、扩大和麝香草酚的安全驾驶加氢和薄荷醇racemisation

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The hydrogenation of thymol and the racemisation of a menthol mixture were investigated as part of the development of novel continuous process for the production of 1-menthol.The key innovation in this 1-menthol process is enzymatic enantioselective resolution of 1-menthol from 8 menthol isomers mixture.This continuous biocatalytic step has significant impact on process economy.The productivity of the enzyme(mass of 1-mentylacetate produced/mass enzyme)is a key performance measurement of this process.The demonstration of the required enzyme productivity was therefore a key objective of the process piloting.The effect of possible side products and impurities on the process also needed to be tested and therefore five cycles of piloting were performed using approximately 500 kg of feed into resolution in each cycle.The required quantities of the racemic menthol mixture were obtained by thymol hydrogenation in pilot plant trickle-bed reactor.Both hydrogenation and racemisation were developed as batch processes at laboratory scale and tested at bench scale in a continuous trickle-bed reactor system and scaled up to a pilot scale trickle-bed reactor.A bench scale trickle-bed reactor was designed,constructed and extensively used in the optimisation of the hydrogenation of thymol to racemic menthol.The process was successfully operated for more than 660 h in a bench scale reactor and subsequently scaled up to a pilot scale trickle-bed reactor.The pilot scale experiments were used to verify process scale-up and generate material for menthol resolution and downstream processing.Both the bench and pilot scale reactors were operated as adiabatic systems and the operation was found to be safe and reliable.Safety problems leading to formation of undesirable hot spots were experienced as consequence of insufficient catalyst wetting,high thymol concentration in the feed(above 40wt.%)and because of possible equipment,operation and power failure.
机译：麝香草酚的加氢和racemisation薄荷醇的混合物进行调查的一部分小说发展的连续过程1-menthol的生产。这种酶1-menthol过程拆分解决1-menthol从8薄荷醇异构体混合物。biocatalytic一步有显著影响经济过程。酶(质量1-mentylacetate生产/质量酶)是一个关键的性能度量的过程。生产力的一个重要目标驾驶过程。产品和杂质的过程需要测试,因此五个周期驾驶进行使用约500公斤的饲料决议在每个周期。需要大量的外消旋薄荷醇百里酚加氢得到的混合物试验厂滴流床反应器。加氢和racemisation发达批处理过程在实验室规模和测试实验室规模在一个连续的滴流床反应器系统和扩大试点规模滴流床反应堆。设计、建造和广泛使用优化加氢的麝香草酚外消旋薄荷醇。操作实验室规模超过660 h反应堆,随后扩大试点滴流床反应器。实验被用来验证过程扩大和为薄荷醇分辨率和生成材料下游加工。规模的反应堆操作作为绝热系统和操作被发现是安全的可靠的。不受欢迎的热点是有经验的催化剂润湿不足的结果,高百里酚浓度提要(40 wt. %以上)和因为可能的设备、操作和权力失败。

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