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首页> 外文期刊>Journal of Cellular Physiology >Serotonin transporter protects the placental cells against apoptosis in caspase 3-independent pathway
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Serotonin transporter protects the placental cells against apoptosis in caspase 3-independent pathway

机译：羟色胺转运体保护胎盘细胞对细胞凋亡在半胱天冬酶三个独立通路

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摘要

Serotonin (5-HT) and its specific transporter, SERT play important roles in pregnancy. Using placentas dissected from 18d gestational SERT-knock out (KO), peripheral 5-HT (TPH1)-KO, and wild-type (WT) mice, we explored the role of 5-HT and SERT in placental functions in detail. An abnormal thick band of fibrosis and necrosis under the giant cell layer in SERT-KO placentas appeared only moderately in TPH1-KO and minimally present in WT placentas. The majority of the changes were located at the junctional zone of the placentas in SERT. The etiology of these findings was tested with TUNEL assays. The placentas from SERT-KO and TPH1-KO showed 49- and 8-fold increase in TUNEL-positive cells without a concurrent change in the DNA repair or cell proliferation compared to WT placentas. While the proliferation rate in the embryos of TPH1-KO mice was 16-fold lower than the rate in gestational age matched embryos of WT or SERT-KO mice. These findings highlight an important role of continuous 5-HT signaling on trophoblast cell viability. SERT may contribute to protecting trophoblast cells against cell death via terminating the 5-HT signaling which changes cell death ratio in trophoblast as well as proliferation rate in embryos. However, the cell death in SERT-KO placentas is in caspase 3-independent pathway.
机译：5 -羟色胺(5 -)及其特定的运输,泽特扮演重要角色在怀孕。从18 d妊娠胎盘解剖和野生型小鼠(WT),我们的作用进行了探讨5,泽特胎盘功能的细节。异常厚的纤维化和坏死在巨大的细胞层SERT-KO胎盘似乎只有适度TPH1-KO和最低限度出现在WT胎盘。变化是位于交界区泽特的胎盘。发现与TUNEL检测化验。从SERT-KO TPH1-KO显示49 -和胎盘8番增加TUNEL-positive细胞没有并发DNA修复或细胞的变化扩散而WT胎盘。增殖率TPH1-KO老鼠的胚胎在妊娠16倍低于年龄匹配的胚胎WT或SERT-KO老鼠。发现强调一个重要的角色连续5 -信号在滋养层细胞生存能力。滋养层细胞与细胞死亡终止细胞5 -信号的变化死亡比率在滋养层在胚胎增殖率。死亡SERT-KO胎盘细胞凋亡蛋白酶三个独立通道。

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