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首页> 外文期刊>Journal of Cellular Physiology >LIGHT Is a Crucial Mediator of Airway Remodeling
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LIGHT Is a Crucial Mediator of Airway Remodeling

机译：光是气道重塑的重要中介

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Chronic inflammatory airway diseases like asthma and chronic obstructive pulmonary disease are major health problems globally. Airway epithelial cells play important role in airway remodeling, which is a critical process in the pathogenesis of diseases. This study aimed to demonstrate that LIGHT, an inflammatory factor secreted by T cells after allergen exposure, is responsible for promoting airway remodeling. LIGHT increased primary human bronchial epithelial cells (HBECs) undergoing epithelial-mesenchymal transition (EMT) and expressing MMP-9. The induction of EMT was associated with increased NF-B activation and p300/NF-B association. The interaction of NF-B with p300 facilitated NF-B acetylation, which in turn, was bound to the promoter of ZEB1, resulting in E-cadherin downregulation. LIGHT also stimulated HBECs to produce numerous cytokines/chemokines that could worsen airway inflammation. Furthermore, LIGHT enhanced HBECs to secrete activin A, which increased bronchial smooth muscle cell (BSMC) migration. In contrast, depletion of activin A decreased such migration. The findings suggest a new molecular determinant of LIGHT-mediated pathogenic changes in HBECs and that the LIGHT-related vicious cycle involving HBECs and BSMCs may be a potential target for the treatment of chronic inflammation airway diseases with airway remodeling. J. Cell. Physiol. 230: 1042-1053, 2015. (c) 2014 Wiley Periodicals, Inc., A Wiley Company
机译：慢性气道炎症性疾病如哮喘和慢性阻塞性肺病全球主要的健康问题。细胞在气道重塑发挥重要的作用,这是一个关键流程的发病机理的疾病。光,通过T细胞炎症因子分泌过敏原暴露后,负责促进气道重塑。主要人类支气管上皮细胞(HBECs)接受epithelial-mesenchymal过渡(EMT)和表达MMP-9。与增加NF-B激活和有关吗p300 / NF-B协会。在与p300促进NF-B乙酰化作用又注定ZEB1的启动子,以上。差别导致钙粘蛋白对这些也刺激HBECs产生无数细胞因子/趋化因子,可能加剧气道炎症。支气管分泌激活素A,也增加平滑肌细胞(BSMC)迁移。苯丙酸诺龙的损耗减少这样的迁移。调查结果显示一个新的分子行列式HBECs LIGHT-mediated致病性变化的LIGHT-related恶性循环有关HBECs和BSMCs可能是一个潜在的目标气道慢性炎症疾病的治疗与气道重塑。1042 - 1053年,2015年。Inc .威利公司

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