Navigating the nucleotide excision repair threshold.

Liu L; Lee J; Zhou P

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Navigating the nucleotide excision repair threshold.

机译：在核苷酸切除修复阈值。

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Nucleotide excision repair (NER) is the primary DNA repair pathway that removes helix-distorting DNA strand damage induced by ultraviolet light irradiation or chemical carcinogens to ensure genome integrity. While the core NER proteins that carry out damage recognition, excision, and repair reactions have been identified and extensively characterized, and the NER pathway has been reconstituted in vitro, the regulatory pathways that govern the threshold levels of NER have not been fully elucidated. This mini-review focuses on recently discovered transcriptional and post-translational mechanisms that specify the capacity of NER, and suggests the potential implications of modulating NER activity in cancer prevention and therapeutic intervention.

机译：核苷酸切除修复(尼珥)是主要的删除helix-distorting DNA修复途径DNA链紫外线诱导的损害辐射或化学致癌物质保证基因组的完整性。进行损伤识别,切除已确定并修复反应广泛的特点,尼珥通路一直在体外重组,监管通路管理尼珥的阈值水平尚未完全阐明。重点是最近发现的转录指定和翻译后机制尼珥的能力,表明潜在的影响调制尼珥活动的癌症预防和治疗干预。

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来源
《Journal of Cellular Physiology》 |2010年第3期|585-589|共5页
作者
Liu L; Lee J; Zhou P;
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作者单位

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College and Weill Cornell Graduate School of Medical Sciences, New York, New York 10065, USA.;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
threshold level; geolocation measurement; Nucleotide Excision RepairDNA Repair PathwayGenetic TranscriptionDNA RepairCarcinogenscancer preventionintervention therapy;

机译：阈值水平,地理位置测量;核苷酸切除RepairDNA修复PathwayGeneticTranscriptionDNA RepairCarcinogenscancerpreventionintervention疗法;

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1. DNA Repair Gene Polymorphisms in the Nucleotide Excision Repair Pathway and Lung Cancer Risk： A Meta-analysis [J] . Chao-rong Mei, Meng Luo, Hong-mei Li, 中国癌症研究：英文版 . 2011,第002期
2. DNA Repair Gene Polymorphisms in the Nucleotide Excision Repair Pathway and Lung Cancer Risk: A Meta-analysis [J] . Chao-rong Mei, Meng Luo, Hong-mei Li, 中国癌症研究（英文版） . 2011,第002期
3. Transcription-coupled nucleotide excision repair in mammalian cells： molecular mechanisms and biological effects [J] . Mafia Fousteri, Leon HF Mullenders 细胞研究：英文版 . 2008,第001期
4. Excision-repair-cross-complement-1 protein as a prognostic factor in patients with advanced non-small cell lung cancer treated with platinum-based first-line chemotherapy [J] . VassalouH., StathopoulosE., FiolitakiG.KoutsopoulosA.VoutsinaA.GeorgouliasV.MavroudisD. Lung cancer: Journal of the International Association for the Study of Lung Cancer . 2013,第2期

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5. Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state. [J] . Shida M, Arakawa A, Ishii RKishishita STakagi TKukimoto Niino MSugano STanaka AShirouzu MYokoyama S Acta crystallographica.Section D. Biological crystallography . 2010,第3期

机译：直接inter-subdomain交互之间切换Hsp70的封闭和开放的形式nucleotide-free nucleotide-binding域状态。
6. JERコンクリート補改修協会に改称 [J] . 防水ジャ—ナル . 2016,第8期

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8. Note: Lambda Excision Revisited: Testing a Model for Synapsis of Prophage Ends [O] . Martin L. Pato 2001

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Navigating the nucleotide excision repair threshold.

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