Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy.

Azmi AS; Mohammad RM

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Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy.

机译：Non-peptidic小分子抑制剂bcl - 2对癌症治疗。

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A critical regulator of the apoptotic machinery is the Bcl-2 family proteins whose over expression confers a protective effect on malignant cells against death signals of apoptosis. Cancer cells that are resistant to various anti-cancer drugs and treatment regimen are found to over express these Bcl-2 proteins such as Bcl-2, Bcl-X(L), Mcl-1, Bcl-w, and A1/Bfl1. In recent years there has been an exponential growth in the identification as well as synthesis of non-peptidic cell permeable small-molecule inhibitors (SMIs) of protein-protein interaction. The focus of this article is on inhibitors of anti-apoptotic protein Bcl-2. This review summarizes an up to date knowledge of the available SMIs, their mode of action as well as their current status in preclinical as well as clinical development.

机译：凋亡机制的关键调节器bcl - 2家族蛋白的过表达授予恶性细胞的保护作用对死亡细胞凋亡的信号。抵抗各种抗癌药物在表达和治疗方案被发现这些bcl - 2这样的bcl - 2蛋白,Bcl-X(左),mcl1 Bcl-w, A1 / Bfl1。一直是指数增长的识别和合成non-peptidic细胞渗透性小分子抑制剂(重度)的蛋白质相互作用。本文的重点是抑制剂抗凋亡蛋白bcl - 2。总结了一个最新的知识重度,他们的行动以及模式他们在临床前以及现状临床的发展。

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来源
《Journal of Cellular Physiology》 |2009年第1期|13-21|共9页
作者
Azmi AS; Mohammad RM;
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作者单位

Department of Pathology, Wayne State University School of Medicine, Detroit Michigan, USA.;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
Protein-Protein Interaction; Sulfones; PyrrolesAntineoplastic Agentscancer cellbcl-2 GenesSulfonamidescancer therapyExponential GrowthTreatment Regimen;

机译：蛋白质交互;砜类;PyrrolesAntineoplasticAgentscancer cellbcl-2 GenesSulfonamidescancertherapyExponential GrowthTreatment养生法;

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Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy.

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