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首页> 外文期刊>Journal of Cellular Physiology >Contact inhibition revisited.
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Contact inhibition revisited.

机译：接触抑制再现。

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Contact inhibition of cell movement was originally defined in the 1950s as a way of interpreting studies that were ethological and statistical in nature. Research done in succeeding decades provided a more detailed study of the initial contact and its consequences for the cell. The behavior called contact inhibition is characterized by the cessation of ruffling and forward movement in the lamellipodium of the cell making the contact. A new ruffling membrane then arises elsewhere on the cell perimeter. A comparison between the contact behavior described in the early literature and that of the nerve growth cone, described recently by Steketee and Tosney, suggests that filopodia mediate the sensing function in both cases. Since transformed cells have fewer filopodia than normal cells, the contact behavior may decline in direct response to the degraded function of filopodia. This new "filopodia focal signal transduction" hypothesis of contact inhibition elevates the filopodia sensing function and the cessation of lamellipodial advance to the highest importance as phenomena underlying the altered behavior of cancer cells.
机译：最初接触抑制的细胞运动在1950年代定义为一种解读方式研究行为学的和统计的大自然。提供了一个更详细的研究最初的联系及其对细胞的影响。行为叫做接触抑制以停止波动在细胞的lamellipodium向前运动使接触。出现在细胞周围。比较之间的接触行为描述在早期的文学和神经生长锥,最近由斯特凯蒂和描述Tosney,表明丝状伪足调解传感功能在这两种情况下。细胞比正常细胞丝状伪足,较少接触行为可能下降的直接回应丝状伪足的降解功能。“丝状伪足焦信号转导”假说接触抑制的调节丝状伪足传感功能和停止lamellipodial重要性最高作为底层的改变行为现象癌细胞。

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