Preparation of ↑(188)Re-RC- 160 Somatostatin Analog: a Peptide for Local/Regional Radiotherapy

P. O. ZAMORA; M. J. MAREK; F. F. (RUSS) KNAPP JR

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Preparation of ↑(188)Re-RC- 160 Somatostatin Analog: a Peptide for Local/Regional Radiotherapy

机译：↑（188）Re-RC-160生长抑素类似物的制备：用于局部/区域放疗的肽

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Conditions are described for the preparation of ↑(188)Re-RC-160. a radiolabeled synthetic peptide derived from an analogue of somatostatin, using a lyopbilized labeling kit containing RC-160 (200 μg) and stannous tartrate to which is added carrier-free ↑(188)Re (β, E↓(max), 2.12 MeV.γ, 155 keV, 10%; T↓(1/2) = 16.7 h). The kits have been radiolabeled with > 2960 MBq (80 mCi) with a high labeling efficiency and no need for subsequent purification. Radiolabeling results in one major peak when analyzed by reverse-phase (RP) HPLC. Presumptive radiolysis was detected al 2.5 h post-labeling; however, a convenient method is described for stabilizing the kits against radiolysis by the post-labeling addition of ascorbic acid. # 1997 Elsevier Science Ltd. All rights reserved

机译：描述了制备↑（188）Re-RC-160的条件。使用含有RC-160（200μg）和酒石酸亚锡的冻干标记试剂盒，添加了无载体的↑（188）Re（β，E↓（max），2.12 MeV，由生长抑素类似物衍生的放射性标记合成肽γ，155keV，10％; T↓（1/2）＝ 16.7h）。该试剂盒已经用> 2960 MBq（80 mCi）进行了放射性标记，标记效率很高，无需后续纯化。当通过反相（RP）HPLC分析时，放射性标记导致一个主要峰。标记后2.5小时检测到推测的放射分解;然而，描述了一种方便的方法，用于通过标记后添加抗坏血酸来稳定试剂盒以防辐射分解。＃1997 Elsevier Science Ltd.保留所有权利

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《Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine》 |1997年第3期|共5页
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P. O. ZAMORA; M. J. MAREK; F. F. (RUSS) KNAPP JR;
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正文语种 eng
中图分类原子核物理学、高能物理学;放射医学;
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1. Preparation of ↑(188)Re-RC- 160 Somatostatin Analog: a Peptide for Local/Regional Radiotherapy [J] . P. O. ZAMORA, M. J. MAREK, F. F. (RUSS) KNAPP JR Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine . 1997,第3期

机译：↑（188）Re-RC-160生长抑素类似物的制备：用于局部/区域放疗的肽
2. Somatostatin receptor-binding peptides suitable for tumor radiotherapy with Re-188 or Re-186. Chemistry and initial biological studies. [J] . Cyr JE, Pearson DA, Wilson DM, Journal of Medicinal Chemistry . 2007,第6期

机译：生长抑素受体结合肽，适合用Re-188或Re-186进行肿瘤放疗。化学和初步生物学研究。
3. Treatment of transplanted tumor of lung adenocarcinoma A549 transfected by human somatostatin receptor subtype 2 (hsstr2) gene with 188Re-RC-160. [J] . Zhao R, Yang W, Wang Z, Nuclear Medicine and Biology . 2010,第8期

机译：188Re-RC-160对人生长抑素受体亚型2（hsstr2）基因转染的肺腺癌A549移植瘤的治疗。
4. Combinatorial synthesis of rhenium-cyclic somatostatin analogs using the novel peptide Backbone Metal-Cyclization(BMC)method [C] . Gil Fridkin, Thomas A.Bonasera, Pninit Litman International Peptide Symposium;European Peptide Symposium . 2005

机译：用新型肽骨架金属环化（BMC）法组合铼环生长抑素类似物的组合合成
5. Rhenium cyclized alpha-MSH analogs, somatostatin analogs and T-antigen avid peptides as imaging and therapeutic agents for tumor targeting. [D] . Cheng, Zhen. 2001

机译：hen环化的α-MSH类似物，生长抑素类似物和T抗原亲和肽可作为肿瘤靶向的成像和治疗剂。
6. Localization of Small‐cell Lung Cancer Xenografts with Iodine‐125‐ Indium‐111‐ and Rhenium‐188‐Somatostatin Analogs [O] . Makoto Hosono, Masako N. Hosono, Thomas Haberberger, 1996

机译：碘125铟111和I 188生长抑素类似物对小细胞肺癌异种移植的定位
7. Interim report on intrathoracic radiotherapy of human small-cell lung carcinoma in nude mice with Re-188-RC-160, a radiolabeled somatostatin analogue [O] . Zamora, P.O., Bender, H., Biersack, H.J., 1995

机译：Re-188-RC-160（一种放射性标记的生长抑素类似物）对裸鼠人小细胞肺癌进行胸内放疗的中期报告
8. Interim report on intrathoracic radiotherapy of human small-cell lung carcinoma in nude mice with Re-188-RC-160, a radiolabeled somatostatin analogue [R] . Zamora, P. O., Bender, H., Biersack, H. J., 1995

机译：Re-188-RC-160（一种放射性标记的生长抑素类似物）对裸鼠人小细胞肺癌进行胸内放疗的中期报告

Preparation of ↑(188)Re-RC- 160 Somatostatin Analog: a Peptide for Local/Regional Radiotherapy

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