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In vivo molecular imaging of [125I]-labeled 3-iodothyronamine: A hibernation-inducing agent

机译:[125I]标记的3-碘胸苷胺的体内分子成像:冬眠诱导剂

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摘要

The present investigation was carried out with the objective of studying in vivo imaging of 3-iodothyronamine (T1AM) compound in mice. A simple and efficient synthesis of [125I]-T1AM was established, and a molecular imaging study was performed using micro-SPECT/CT at 1h post-injection of [125I]-T1AM. Imaging studies revealed the activity in the gastrointestinal tract and liver, indicating that [125I]-T1AM was distributed primarily in the liver, and excreted into the gastrointestinal tract through a bile duct. ? 2012 Elsevier Ltd.
机译:进行本研究的目的是研究小鼠中的3-碘甲状腺素(T1AM)化合物的体内成像。建立了[125I] -T1AM的简单有效合成方法,并在注射[125I] -T1AM后1小时使用micro-SPECT / CT进行了分子成像研究。影像学研究揭示了在胃肠道和肝脏中的活性,表明[125I] -T1AM主要分布在肝脏中,并通过胆管排入胃肠道。 ? 2012爱思唯尔有限公司

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