The Synthesis of No-carrier-added [↑(11)C]Urea from [↑(11)C]Carbon Dioxide and Application to [↑(11)C]Uracil Synthesis

P. K. CHAKRABORTY; T. J. MANGNER; H. T. CHUGANI

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The Synthesis of No-carrier-added [↑(11)C]Urea from [↑(11)C]Carbon Dioxide and Application to [↑(11)C]Uracil Synthesis

机译：由[↑（11）C]二氧化碳合成无载体的[↑（11）C]尿素及其在[↑（11）C]尿嘧啶合成中的应用

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No-carrier-added [↑(11)C]urea has been synthesized by bubbling cyclotron-produced [↑(11)C]carbon dioxide directly into a tetrahydrofuran solution of lithium bis(trimethylsilyl)amide, followed by hydrolysis of the C-11 labeled adduct with aqueous ammonium chloride. Using this simple, one-pot method, [↑(11)C]urea was produced in 55-70% radiochemical yield (decay-corrected) in t6 min following end-of-bombardment 1or in l0 min following the introduction of the [↑(11)C]carbon dioxide). The [↑(11)C]urea thus produced was converted to [↑(11)C]uracil (carrier-added) in 40-75% decay-corrected radiochemical yield by condensation with diethyl malate in presence of fuming sulfuric acid. # 1997 Elsevier Science Ltd

机译：通过将回旋加速器产生的[↑（11）C]二氧化碳直接鼓泡到双（三甲基甲硅烷基）酰胺锂的四氢呋喃溶液中，然后水解C-，可以合成没有添加载体的[↑（11）C]脲11用氯化铵水溶液标记的加合物。使用这种简单的一锅法，在轰炸1结束后的t6分钟内或引入[的[l]之后的10分钟内）以55-70％的放射化学收率（校正后的衰变）生产了[↑（11）C]尿素。 ↑（11）C]二氧化碳）。通过在发烟硫酸存在下与苹果酸二乙酯缩合，将由此产生的[↑（11）C]脲以40-75％衰减校正的放射化学产率转化为[↑（11）C]尿嘧啶（添加了载体）。＃1997爱思唯尔科学有限公司

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《Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine》 |1997年第5期|共3页
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P. K. CHAKRABORTY; T. J. MANGNER; H. T. CHUGANI;
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中图分类原子核物理学、高能物理学;放射医学;
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1. The Synthesis of No-carrier-added [↑(11)C]Urea from [↑(11)C]Carbon Dioxide and Application to [↑(11)C]Uracil Synthesis [J] . P. K. CHAKRABORTY, T. J. MANGNER, H. T. CHUGANI Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine . 1997,第5期

机译：由[↑（11）C]二氧化碳合成无载体的[↑（11）C]尿素及其在[↑（11）C]尿嘧啶合成中的应用
2. Selective synthesis of [2-C-11]2-iodopropane and [1-C-11]iodoethane using the loop method by reacting methylmagnesium bromide with [C-11]carbon dioxide [J] . Zhang MR, Ogawa M, Yoshida Y, Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine . 2006,第2期

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6. Synthesis of 11CBexarotene by Cu-Mediated11CCarbon Dioxide Fixation and Preliminary PET Imaging [O] . BenjaminH. Rotstein, Jacob M. Hooker, Jiyeon Woo, 2014

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机译：使用钯（I）二聚体的快速羰基偶联反应：在（CO）-C-11-radiolabelling上用于PET示踪剂的合成：在11CO-radiolabelling上用于PET示踪剂的合成的应用

The Synthesis of No-carrier-added [↑(11)C]Urea from [↑(11)C]Carbon Dioxide and Application to [↑(11)C]Uracil Synthesis

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