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首页> 外文期刊>Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine >Determination of boron concentration in blood and tissue samples from patients with liver metastases of colorectal carcinoma using Prompt Gamma Ray Activation Analysis (PGAA).
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Determination of boron concentration in blood and tissue samples from patients with liver metastases of colorectal carcinoma using Prompt Gamma Ray Activation Analysis (PGAA).

机译:使用提示伽马射线活化分析(PGAA)测定大肠癌肝转移患者血液和组织样品中的硼浓度。

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摘要

As part of the studies on Boron Neutron Capture Therapy at the University of Mainz, Germany, a clinical trial has been started in which, four patients suffering from liver metastases of colorectal carcinoma have been enrolled. Specimens of blood and healthy tissue samples taken from the patients were measured at the PGAA facilities at the HFR in Petten, The Netherlands, and at the FRM II in Munich, Germany. From the measured boron concentrations, pharmacokinetic curves and blood-to-tissue concentration ratios were produced.
机译:作为德国美因兹大学硼中子捕获疗法研究的一部分,已经开始了一项临床试验,其中招募了四名患有结肠直肠癌肝转移的患者。在荷兰佩滕HFR的PGAA设施和德国慕尼黑的FRM II的PGAA设施中对从患者身上采集的血液和健康组织样本进行了测量。从测得的硼浓度,药代动力学曲线和血液与组织的浓度比得出。

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