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首页> 外文期刊>Journal of diabetes. >Pre‐existing type 2 diabetes is an adverse prognostic factor in patients with renal cell carcinoma
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Pre‐existing type 2 diabetes is an adverse prognostic factor in patients with renal cell carcinoma

机译：提前现有2型糖尿病是一种不利肾细胞的患者的预后因素癌

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Abstract Background Diabetes is a risk factor for various cancers, but its prognostic role in renal cell carcinoma (RCC) is controversial and understudied. This study investigated the prognostic value of type 2 diabetes (T2D) in RCC patients. Methods The clinicopathological and follow‐up data of 451 RCC patients undergoing radical or partial nephrectomy at the First Hospital of Shanxi Medical University from 2013 to 2018 were reviewed. Associations of T2D with clinicopathological parameters of RCC were evaluated using the Kaplan‐Meier method for survival estimates and Cox regression univariate and multivariate analyses. Results Of 451 patients, 74 (16.4%) had T2D. These patients were older, had a higher body mass index, higher incidence rates of hypertension and cardiovascular morbidity, a higher rate of laparoscopic surgery, and smaller neoplasms (all P ??.05). Patients with T2D exhibited shorter overall survival (OS; P = .009), cancer‐specific survival (CSS; P = .043), and recurrence‐free survival (RFS; P = .008) than patients without T2D. Fuhrman grade (hazard ratio [HR] 2.542, 95% confidence interval [CI] 1.115‐5.795, P = .026) and T2D (HR 3.391, CI 1.458‐7.886, P = .005) were independent predictors of OS; T2D was an independent predictor of CSS (HR = 4.637, 95% CI 1.420‐15.139, P = .011) and RFS (HR 3.492, 95% CI 1.516‐8.044, P = .003). Conclusions Renal cell carcinoma patients with T2D have a shorter OS and higher recurrence rate and mortality risk than those without T2D.
机译：抽象的背景糖尿病的一个危险因素各种癌症,但其在肾脏预后的作用细胞癌(RCC)是有争议的可以理解。2型糖尿病的预后价值在RCC (T2D)病人。遵循量451 RCC患者的数据在第一次切除或部分切除医院从2013年山西医科大学综述了2018年。碾压混凝土是临床病理参数评估使用的卡普兰Meier应承担的方法生存和Cox回归估计单变量和多变量分析。T2D患者中,74例(16.4%)。年龄的增长,身体质量指数较高,高高血压的发病率心血管疾病的发病率,更高的速度腹腔镜手术,较小的肿瘤(所有P & ? . 05)。总生存期(OS);生存(CSS;生存(RFS;T2D。可信区间(CI) 1.115还是5.795,P = .026)和T2D (HR 3.391,可信区间1.458还是7.886,P = .005)操作系统的独立预测指标;独立预测指标的CSS (HR = 4.637, 95% CI1.420还是15.139,P = .011)和RFS (HR 3.492, 95%可信区间1.516还是8.044,P = .003)。癌患者T2D的操作系统和较短较高的复发率和死亡率风险比那些没有T2D。

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