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首页> 外文期刊>Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine >Generic models for radionuclide dosimetry: 11C-, 18F- or 75Se-labelled amino acids.
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Generic models for radionuclide dosimetry: 11C-, 18F- or 75Se-labelled amino acids.

机译：放射性核素剂量测定的通用模型：11C，18F或75Se标记的氨基酸。

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摘要

A generic biokinetic model was developed for use in the assessment of the internal dose received by human subjects injected with amino acids labelled with 11C (T1/2 = 0.34 h, beta+, gamma), 18F(T1/2 = 1.83 h, beta+, gamma) or 75Se (T1/2 = 119.8 d, beta-, gamma). This generic model was used in conjunction with the MIRDOSE 3 computer programme to calculate radiation doses to adults; these radiation doses were compared with those calculated using compound-specific models for two [11C]-, and eight [18F]-labelled amino acids and [75Se]selenomethionine. In general, the effective doses, as well as the organ and tissue doses, calculated using the generic model agreed within a factor of 2 or less, with those calculated using compound-specific models; the generic model tended to over-, rather than underestimate the organ and tissue doses. It was concluded that for 11C- and 18F-labelled amino acids and for 75Se-labelled amino acids or their analogues, the single generic biokinetic model could be applied for general radiation protection purposes.
机译：已开发出通用的生物动力学模型，用于评估注射有11C（T1 / 2 = 0.34 h，beta +，γ），18F（T1 / 2 = 1.83 h，beta +， γ）或75Se（T1 / 2 = 119.8 d，β-，γ）。该通用模型与MIRDOSE 3计算机程序结合使用，可以计算出成年人的辐射剂量。将这些辐射剂量与使用化合物特异性模型计算的两个[11C]-和八个[18F]标记氨基酸和[75Se]硒代蛋氨酸的辐射剂量进行了比较。通常，使用通用模型计算的有效剂量以及器官和组织剂量与使用化合物特异性模型计算的有效剂量相差不超过2倍。通用模型倾向于高估而不是低估器官和组织的剂量。结论是，对于11 C和18 F标记的氨基酸以及75 Se标记的氨基酸或其类似物，可以将单个通用生物动力学模型用于一般的辐射防护目的。

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