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首页> 外文期刊>Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine >Model 3500 125I brachytherapy source dosimetric characterization.
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Model 3500 125I brachytherapy source dosimetric characterization.

机译：3500 125I型近距离放射源剂量学表征。

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摘要

Low-energy gamma-emitting isotopes encapsulated for permanent implant are routinely applied in brachytherapy, most notably for prostate cancer. Before clinical use of a new source design, a full dosimetric analysis and standardized calibration are essential. Results of experimental measurement and analysis are reported here for the I-Plant (Implant Sciences Corporation) 125I source, model 3500. Dose measurements were made using standard methods employing thermoluminscent dosimeters in a water equivalent plastic phantom. Precision machined bores in the phantom located dosimeters and source(s) in a reproducible fixed geometry providing for transverse-axis and angular dose profiles over a range of distances from 0.17 to 10 cm. The data were analyzed in terms of parameters recommended by AAPM TG-43. The dose-rate constant, delta = 1.01 cGy/h U (+/-6%) (1 U = 1 cGy cm2 h(-1)), was evaluated with reference to a TG-51 calibrated 60Co standard, accounting for dosimeter response differences between 60Co and 125I photons. The radial dose function, g(r), the anisotropy function, F(r, theta), the anisotropy factor, phi(an)(r), and the point-source approximation anisotropy constant, phi(an), were derived from one- and two-dimensional dose distribution data measured in the phantom, accounting for finite dosimeter volume and with attention to inter-chip effects. The results confirm prior dosimetric characterization of the model 3500, and indicate that the new source is comparable to the MED3631-A/M and 6702 source designs and may substitute for model 6711 in permanent implants for the treatment of prostate cancer.
机译：封装用于永久植入物的低能伽马发射同位素通常用于近距离放射治疗，尤其是前列腺癌。在临床上使用新来源设计之前，必须进行全面的剂量分析和标准化校准。这里报告了I-Plant（Implant Sciences Corporation）125I离子源，型号3500的实验测量和分析结果。剂量测量是使用标准的方法，在相当于水的塑料体模中使用热发光剂量计进行的。幻影定位剂量计和源中的精密加工孔具有可重现的固定几何形状，可在0.17至10 cm的距离范围内提供横轴和角剂量分布。根据AAPM TG-43推荐的参数对数据进行了分析。剂量率常数delta = 1.01 cGy / h U（+/- 6％）（1 U = 1 cGy cm2 h（-1））是参照TG-51校准的60Co标准品（剂量计）进行评估的60Co和125I光子之间的响应差异。径向剂量函数g（r），各向异性函数F（r，θ），各向异性因子phi（an）（r）和点源近似各向异性常数phi（an）分别从在幻像中测量的一维和二维剂量分布数据，说明了有限的剂量计体积，并注意了芯片间的影响。结果证实了模型3500的先前剂量学特性，并表明新来源可与MED3631-A / M和6702来源设计相媲美，并且可以替代永久植入物中的6711模型来治疗前列腺癌。

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