Radiation sterilization of fluoroquinolones in solid state: investigation of effect of gamma radiation and electron beam.

Singh BK; Parwate DV; Dassarma IB; Shukla SK

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Radiation sterilization of fluoroquinolones in solid state: investigation of effect of gamma radiation and electron beam.

机译：固态氟喹诺酮类化合物的辐射灭菌：γ射线和电子束的作用研究。

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The effect of gamma radiation from (60)Co source and 2MeV electron beam was studied on two fluoroquinolone antibiotics viz norfloxacin and gatifloxacin in the solid state. The changes in reflectance spectrum, yellowness index, vibrational characteristics, thermal behavior, UV spectrum, chemical potency (HPLC) and microbiological potency were investigated. ESR measurement gave the number of free radical species formed and their population. The nature of final radiolytic impurities was assessed by studying the HPLC impurity profile. Both norfloxacin and gatifloxacin were observed to be radiation resistant, and did not show significant changes in their physico-chemical properties. They could be radiation sterilized at a dose of 25kGy.

机译：研究了来自（60）Co源和2MeV电子束的γ射线对两种氟喹诺酮类抗生素即诺氟沙星和加替沙星固态的影响。研究了反射光谱，泛黄指数，振动特性，热行为，紫外光谱，化学效能（HPLC）和微生物效能的变化。 ESR测量给出了形成的自由基种类的数量及其种群。通过研究HPLC杂质分布图评估了最终的放射性杂质的性质。观察到诺氟沙星和加替沙星都具有抗辐射性，并且在其理化性质上未显示出显着变化。它们可以以25kGy的剂量进行辐射灭菌。

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《Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine》 |2010年第9期|共9页
作者
Singh BK; Parwate DV; Dassarma IB; Shukla SK;
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正文语种 eng
中图分类放射医学;
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1. Radiation sterilization of fluoroquinolones in solid state: investigation of effect of gamma radiation and electron beam. [J] . Singh BK, Parwate DV, Dassarma IB, Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine . 2010,第9期

机译：固态氟喹诺酮类化合物的辐射灭菌：γ射线和电子束的作用研究。
2. Degradation studies of a commercial radiation-resistant polypropylene sterilized by gamma and electron beam technology before and after subsequent accelerated aging cycles [J] . Kremser Thomas, Susoff Markus, Roth Stefan, Journal of Applied Polymer Science . 2020,第9a10期

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3. Impact of sterilization by electron beam, gamma radiation and X- rays on electrospun poly-(ε-caprolactone) fiber mats [J] . de Cassan Dominik, Hoheisel Anna Lena, Glasmacher Birgit, Journal of materials science . 2019,第4期

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4. Investigations of focusing conditions of the 1.2kW CO_(2) cw laser radiation beam. [C] . G. Rabczuk, P. Kukiello, SPIE Laser Technology . 1995

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5. Fracture resistance behaviour of gamma-irradiation sterilized cortical bone protected with a ribose pre-treatment. [D] . Woodside, Carman Mitchell. 2015

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6. Low Energy Electron Irradiation Is a Potent Alternative to Gamma Irradiation for the Inactivation of (CAR-)NK-92 Cells in ATMP Manufacturing [O] . Lia Walcher, Ann-Kathrin Kistenmacher, Charline Sommer, 2021

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7. A case of mycosis fungoides with combination therapy of systemic administration of interferon .GAMMA. and topical irradiation of electron beam. [O] . Gen WATANABE, Norio OOHASHI, Toshinari TANABE, 1994

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8. Effect of Aliphatic Alcohols as Radiation Protection on the Radiation Sterilization of Antibiotics by gamma Rays of Cobalt 60 [R] . Arumbinang, H., Zainul, K., Soediromargoso, S., 1978

机译：脂肪醇作为辐射防护剂对γ射线γ射线对抗生素辐射灭菌的影响

Radiation sterilization of fluoroquinolones in solid state: investigation of effect of gamma radiation and electron beam.

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