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首页> 外文期刊>Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine >Accumulation of boron compounds to tumor with polyethylene-glycol binding liposome by using neutron capture autoradiography.
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Accumulation of boron compounds to tumor with polyethylene-glycol binding liposome by using neutron capture autoradiography.

机译：通过使用中子俘获放射自显影术，结合聚乙二醇的脂质体将硼化合物积累到肿瘤中。

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摘要

The cytotoxic effect of boron neutron capture therapy (BNCT) is due to a nuclear reaction between (10)B and thermal neutrons. It is necessary to accumulate the (10)B atoms to the tumor cells selectively for effective BNCT. In order to achieve an accurate measurement of (10)B concentrations in the biological samples, we employed a technique of neutron capture autoradiography (NCAR) of the sliced whole-body samples of tumor bearing mice using CR-39 plastic track detectors. The CR-39 detectors attached with samples were exposed to thermal neutrons in the thermal column of the TRIGA II reactor at the Institute for Atomic Energy, Rikkyo University and thermal neutron facility of Paul Scherer Institute(PSI). We obtained NCAR images for mice injected intraveneously by (10)B-PEG liposome, (10)B-transferrin-PEG liposome, or (10)B-bare liposome. The (10)B concentrations in the tumor tissue of mice were estimated by means of [Formula: see text] -track density measurements. In this study, we can increase the accumulation of (10)B atoms in the tumor tissues by binding polyethylene-glycol chains to the surface of liposome, which increase the retention in the blood flow and escape the phagocytosis by reticulo-endothelial systems. Therefore, we will be able to apply NCAR technique for selection of effective (10)B carrier in BNCT for cancer.
机译：硼中子捕获疗法（BNCT）的细胞毒性作用是由于（10）B与热中子之间的核反应所致。为了有效的BNCT，必须选择性地将（10）B原子积累到肿瘤细胞中。为了实现对生物样品中（10）B浓度的准确测量，我们采用CR-39塑料径迹检测器对切片的荷瘤小鼠全身样品进行中子捕获放射自显影（NCAR）。附有样品的CR-39检测器暴露于Rikkyo大学原子能研究所TRIGA II反应堆的热柱中的热中子和Paul Scherer研究所（PSI）的热中子中。我们获得了由（10）B-PEG脂质体，（10）B-转铁蛋白-PEG脂质体或（10）B-裸露脂质体静脉注射的小鼠的NCAR图像。小鼠的肿瘤组织中的（10）B浓度通过[式：见正文]轨迹密度测量来估计。在这项研究中，我们可以通过将聚乙二醇链结合到脂质体的表面上来增加（10）B原子在肿瘤组织中的积累，从而增加血流中的滞留并逃避网状内皮系统的吞噬作用。因此，我们将能够将NCAR技术应用于癌症BNCT中有效（10）B载体的选择。

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