Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti tumor agent.

Bapat K; Chintalwar GJ; Pandey U; Thakur VS; Sarma HD; Samuel G; Pillai MR; Chattopadhyay S; Venkatesh M

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Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti tumor agent.

机译：放射性碘化的补骨脂酚作为抗肿瘤剂的制备及体外评价。

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Bakuchiol, extracted from the plant Psoralea corylifolia, has been proven to have anti-tumor, cytotoxic, anti-microbial and anti-inflammatory activity. In order to study if radiolabeled bakuchiol exhibits enhanced cytotoxicity, bakuchiol was radiolabeled with (125)I. In-vitro uptake studies of (125)I-bakuchiol were carried out using LS-A (lymphosarcoma) and barcl-95 (radiation-induced thymic lymphoma) ascitic and solid tumor cells of murine origin. In both LS-A and barcl-95, (125)I-bakuchiol showed significant uptake. Viability studies showed that the radioiodinated compound showed greater cytotoxic effect than bakuchiol.

机译：从植物补骨脂（Psoralea corylifolia）中提取的爆酚已被证明具有抗肿瘤，细胞毒性，抗微生物和抗炎活性。为了研究放射性标记的补骨脂酚是否表现出增强的细胞毒性，对补骨脂酚进行了（125）I放射性标记。使用鼠源的LS-A（淋巴肉瘤）和barcl-95（放射诱发的胸腺淋巴瘤）腹水和实体瘤细胞进行了（125）I-巴库酚的体外摄取研究。在LS-A和barcl-95中，（125）I-补骨脂酚均显示出明显的摄取。生存力研究表明，放射性碘标记的化合物显示出比补骨脂酚更大的细胞毒性作用。

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来源
《Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine》 |2005年第3期|共5页
作者
Bapat K; Chintalwar GJ; Pandey U; Thakur VS; Sarma HD; Samuel G; Pillai MR; Chattopadhyay S; Venkatesh M;
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正文语种 eng
中图分类特种医学;
关键词
bakuchiol; Neoplasms; radiolabeled; Preparation of bowel for procedure; uptake; 肿瘤;

机译：补骨脂酚;肿瘤;放射性标记;准备肠程序;摄取;肿瘤;

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机译：放射性碘化的补骨脂酚作为抗肿瘤剂的制备及体外评价。
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Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti tumor agent.

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