...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Circulation. Genomic and precision medicine. >Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling and Precision Medicine A Scientific Statement From the American Heart Association
【24h】

Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling and Precision Medicine A Scientific Statement From the American Heart Association

机译：诱导多能干细胞对心血管建模和精密医学疾病美国心脏科学声明协会

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Induced pluripotent stem cells (iPSCs) offer an unprecedented opportunity to study human physiology and disease at the cellular level. They also have the potential to be leveraged in the practice of precision medicine, for example, personalized drug testing. This statement comprehensively describes the provenance of iPSC lines, their use for cardiovascular disease modeling, their use for precision medicine, and strategies through which to promote their wider use for biomedical applications. Human iPSCs exhibit properties that render them uniquely qualified as model systems for studying human diseases: they are of human origin, which means they carry human genomes; they are pluripotent, which means that in principle, they can be differentiated into any of the human body’s somatic cell types; and they are stem cells, which means they can be expanded from a single cell into millions or even billions of cell progeny. iPSCs offer the opportunity to study cells that are genetically matched to individual patients, and genome-editing tools allow introduction or correction of genetic variants. Initial progress has been made in using iPSCs to better understand cardiomyopathies, rhythm disorders, valvular and vascular disorders, and metabolic risk factors for ischemic heart disease. This promising work is still in its infancy. Similarly, iPSCs are only just starting to be used to identify the optimal medications to be used in patients from whom the cells were derived. This statement is intended to (1) summarize the state of the science with respect to the use of iPSCs for modeling of cardiovascular traits and disorders and for therapeutic screening; (2) identify opportunities and challenges in the use of iPSCs for disease modeling and precision medicine; and (3) outline strategies that will facilitate the use of iPSCs for biomedical applications. This statement is not intended to address the use of stem cells as regenerative therapy, such as transplantation into the body to treat ischemic heart disease or heart failure.
机译：诱导多能干细胞(万能)提供了一个研究人类前所未有的机会生理学和疾病在细胞水平上。他们也有可能成为杠杆例如,精密医学的实践个性化的药物测试。全面描述了iPSC的出处线,用于心血管疾病建模、精密医学使用促进他们的广泛的策略用于生物医学应用。表现出独特的属性,呈现它们合格作为研究人类的模型系统疾病:它们是人类的起源,这意味着他们把人类基因组;这意味着在原则上,他们可以吗分化成人体的任何体细胞类型;这意味着他们可以扩展从单一细胞变成数百万甚至数十亿的细胞后代。细胞基因匹配的个人让患者和基因编辑工具遗传变异的介绍或校正。用万能干细胞已取得初步进展更好地理解心肌病,节奏疾病、瓣膜及血管疾病缺血性心脏代谢风险因素疾病。初级阶段。用于识别的最佳药物用于患者的细胞派生的。总结科学与尊重的状态使用万能的建模心血管特征和障碍治疗筛选;和挑战的使用万能干细胞疾病建模和精密医学;策略,以促进万能的使用为生物医学应用。不是为了解决使用干细胞再生疗法,如移植治疗缺血性心脏病或进入体内心力衰竭。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号