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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Relation between human papillomavirus positivity and p16 expression in head and neck carcinomas--a tissue microarray study.
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Relation between human papillomavirus positivity and p16 expression in head and neck carcinomas--a tissue microarray study.

机译：人乳头瘤病毒阳性与头颈癌p16表达之间的关系-组织芯片研究。

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摘要

Overexpression of p16 has been demonstrated to be strongly related to the presence of HPV16, 18. Squamous cell carcinoma of the head and neck has been shown to be associated with human papillomavirus (HPV) infection. The main aim of this study was to investigate the relationship between HPV presence and p16 expression in a representative collection of 60 head and neck carcinomas by tissue microarrays. The presence of HPV (HPV6, 11-low risk, HPV16, 18-high risk) was detected by applying in situ hybridisation. P-16 protein expression was detected immunohistochemically. HPV6, 11 positivity was observed in 10 out of 60 carcinomas. HPV16, 18 presence was found in 30 out of 60 tumours. P-16 expression was detected in 35 out of 60 tumours. A statistically significant relationship was demonstrated between HPV16, 18 presence and increased expression of p16. Also the HPV6, 11 presence was significantly correlated with p16 immunoreactivity. Additionally, this study demonstrates that it is possible to analyse p16 expression and HPV presence by tissue microarrays.
机译：已经证明p16的过表达与HPV16的存在密切相关。18头颈部鳞状细胞癌已被证明与人乳头瘤病毒（HPV）感染有关。这项研究的主要目的是通过组织微阵列研究代表性的60例头颈癌中HPV的存在与p16表达之间的关系。通过原位杂交检测HPV的存在（HPV6、11低风险，HPV16、18高风险）。免疫组织化学检测P-16蛋白表达。 HPV6在60例癌症中有10例阳性。 HPV16在60个肿瘤中的30个中发现18个。在60个肿瘤中的35个中检测到P-16表达。在HPV16、18的存在与p16表达增加之间显示出统计学上的显着关系。 HPV6、11的存在也与p16免疫反应性显着相关。此外，这项研究表明，可以通过组织微阵列分析p16表达和HPV的存在。

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