Multidrug resistance-associated protein (MRP) mediated transport of daunomycin and leukotriene C4 (LTC4) in isolated plasma membrane vesicles.

Ding GY; Shen T; Center MS

首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Multidrug resistance-associated protein (MRP) mediated transport of daunomycin and leukotriene C4 (LTC4) in isolated plasma membrane vesicles.

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Multidrug resistance-associated protein (MRP) mediated transport of daunomycin and leukotriene C4 (LTC4) in isolated plasma membrane vesicles.

机译：多药耐药相关蛋白（MRP）介导的道诺霉素和白三烯C4（LTC4）在分离的质膜囊泡中的转运。

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Studies have been carried out to examine in vitro drug transport in plasma membrane vesicles isolated from HL60/ADR cells that overexpress MRP. The results demonstrate that glutathione (GSH) enhances transport of daunomycin. A greater increase in transport activity occurs when the reaction is carried out in the presence of both GSH and sodium chloride. Sodium chloride alone has no effect on daunomycin transport. It has also been observed that GSH in the presence of sodium chloride induces a major increase in the transport level of LTC4. Thus far, no metal ion other than sodium chloride has been found to be active in the drug transport system. Kinetic analysis reveals that GSH in the presence of sodium chloride greatly reduces Km and increases Vmax, for daunomycin. Additional studies show that ATPase activity in isolated plasma membrane from HL60/ADR cells is greatly enhanced in the presence of both GSH and sodium chloride. These results suggest the possibility that GSH and sodium chloride stimulate MRP-mediated transport as a result of increased ATPase activity.

机译：已经进行了研究以检查从过度表达MRP的HL60 / ADR细胞分离出的质膜囊泡中的体外药物转运。结果表明，谷胱甘肽（GSH）增强了道诺霉素的转运。当反应在GSH和氯化钠同时存在下进行时，运输活性会大大提高。单独的氯化钠对道诺霉素的运输没有影响。还已经观察到，在氯化钠存在下的GSH引起LTC4转运水平的大幅增加。迄今为止，没有发现除氯化钠以外的金属离子在药物转运系统中具有活性。动力学分析表明，对于道诺霉素，在氯化钠存在下的谷胱甘肽大大降低Km并增加Vmax。其他研究表明，在存在GSH和氯化钠的情况下，从HL60 / ADR细胞分离的质膜中的ATPase活性大大提高。这些结果表明，由于ATPase活性增加，GSH和氯化钠可能刺激MRP介导的转运。

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《Anticancer Research: International Journal of Cancer Research and Treatment》 |1999年第4b期|共6页
作者
Ding GY; Shen T; Center MS;
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正文语种 eng
中图分类肿瘤学;
关键词
ABC Transporters; Daunorubicin; Drug Resistance; Multiple; Leukotriene C4; ABC转运子; 柔红霉素; 抗药性; 多药; 白三烯C4;

机译：ABC Transporters;Daunorubicin;Drug Resistance;Multiple;Leukotriene C4;ABC转运子;柔红霉素;抗药性;多药;白三烯C4;

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1. Multidrug resistance-associated protein (MRP) mediated transport of daunomycin and leukotriene C4 (LTC4) in isolated plasma membrane vesicles. [J] . Ding GY, Shen T, Center MS Anticancer Research: International Journal of Cancer Research and Treatment . 1999,第4B期

机译：多药耐药相关蛋白（MRP）介导的道诺霉素和白三烯C4（LTC4）在分离的质膜囊泡中的转运。
2. Limited brain distribution of (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3(oat3/slc22a8)and multidrug resistance-associated protein 4 (mrp4/abcc4) [J] . Ose A, Ito M, Kusuhara H, Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2009,第2期

机译：（3R，4R，5S）-4-乙酰胺基-5-氨基-3-（1-乙基丙氧基）-1-环己烯-1-羧酸磷酸盐（Ro 64-0802）的有限脑分布，奥司他韦的药理活性形式，通过有机阴离子转运蛋白3（燕麦3 / slc22a8）和多药耐药相关蛋白4（mrp4 / abcc4）介导的跨血脑屏障的主动外排
3. Flow cytometric monitoring of multidrug drug resistance protein 1 (MRP1/ABCC1) -mediated transport of 2',7'-bis-(3-carboxypropyl)-5-(and-6)- carboxyfluorescein (BCPCF) into human erythrocyte membrane inside-out vesicles. [J] . Bobrowska-Hagerstrand M, Wrobel A, Rychlik B, Molecular membrane biology . 2007,第5a6期

机译：流式细胞仪监测多药耐药蛋白1（MRP1 / ABCC1）介导的2'，7'-双-（3-羧丙基）-5-（和-6）-羧基荧光素（BCPCF）向人红细胞膜内部的转运出囊泡。
4. Bile salt and glutathione coefflux mediated by multidrug resistance protein MRP4 (ABCC4), a basolateral transporter of the hepatocyte [C] . M. RIUS, A. T. NIES, A. F. HOFMANN, Falk Symposium . 2005

机译：胆汁盐和谷胱甘肽Cofflux由多药抗性蛋白MRP4（ABCC4）介导的肝细胞的基底外侧转运蛋白
5. The Drosophila ATP-Binding Cassette transporter gene dMRP is related to the human Multidrug Resistance-associated Protein (MRP) family and functions as a xenobiotic transporter. [D] . Cogbill, Jolene Noelani Tarnay. 2008

机译：果蝇ATP结合盒式转运蛋白基因dMRP与人类多药耐药相关蛋白（MRP）家族有关，并作为外源生物转运蛋白。
6. Interaction between the Bound Mg•ATP and the Walker A Serine Residue in NBD2 of Multidrug Resistance-Associated Protein MRP1 Plays a Crucial Role for the ATP-Dependent Leukotriene C4 Transport [O] . Runying Yang, Robert Scavetta, Xiu-bao Chang -1

机译：结合的Mg•ATP与多药耐药相关蛋白MRP1的NBD2中的Walker A丝氨酸残基之间的相互作用在ATP依赖性白三烯C4转运中起关键作用
7. Multidrug Resistance-Associated Protein 2 (MRP2) Mediated Transport of Oxaliplatin-Derived Platinum in Membrane Vesicles. [O] . Khine Myint, Yan Li, James Paxton, 2015

机译：多药耐药相关蛋白2（mRp2）介导的奥沙利铂衍生铂在膜囊泡中的转运。

Multidrug resistance-associated protein (MRP) mediated transport of daunomycin and leukotriene C4 (LTC4) in isolated plasma membrane vesicles.

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