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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Mast cell and eosinophil interaction in gastric carcinomas: ultrastructural observations.
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Mast cell and eosinophil interaction in gastric carcinomas: ultrastructural observations.

机译：胃癌中肥大细胞与嗜酸性粒细胞的相互作用：超微结构观察。

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摘要

BACKGROUND: An increase in the number of mastocytes has been described in some human neoplasms, mainly in gastric and colorectal cancer. MATERIALS AND METHODS: A case of diffuse-type gastric carcinoma, mainly infiltrated by eosinophils and mast cells, was studied using light and electron microscopy. RESULTS: Using light microscopy, cell clusters containing one mast cell and one to three eosinophils were found in the tumour stroma. Electron microscopy of this unusual stromal element revealed that mast cells established areas of junctions with eosinophils. Moreover, focal polarized exocytosis of mast cell granules was found in the areas of junctions with eosinophils. Eosinophils in contact with mast cells showed signs of important in situ activation, such as alterations in the size and number of granules, cytoplasmic vacuoles, and scattered extracellular granules. CONCLUSION: Our ultrastructural study provides morphological evidence of cross-talk between activated mast cells and eosinophils that may playan important role in the enhancement of host immunity against cancer cells.
机译：背景：在某些人类肿瘤中，主要是在胃癌和大肠癌中，已经描述了肥大细胞数量的增加。材料与方法：使用光学和电子显微镜研究了一例主要由嗜酸性粒细胞和肥大细胞浸润的弥漫型胃癌。结果：通过光学显微镜观察，在肿瘤基质中发现了含有一个肥大细胞和一到三个嗜酸性粒细胞的细胞团。电子显微镜观察到这种异常的基质元素显示肥大细胞与嗜酸性粒细胞建立了连接区域。此外，在与嗜酸性粒细胞交界的区域发现了肥大细胞颗粒的局灶性极化胞吐作用。与肥大细胞接触的嗜酸性粒细胞显示出重要的原位活化迹象，例如颗粒大小和数量，细胞质液泡和分散的细胞外颗粒的改变。结论：我们的超微结构研究提供了激活的肥大细胞与嗜酸性粒细胞之间串扰的形态学证据，这可能在增强宿主对癌细胞的免疫力中起重要作用。

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