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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Maspin expression was involved in colorectal adenoma-adenocarcinoma sequence and liver metastasis of tumors.
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Maspin expression was involved in colorectal adenoma-adenocarcinoma sequence and liver metastasis of tumors.

机译：Maspin的表达与大肠腺瘤-腺癌序列和肿瘤肝转移有关。

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BACKGROUND: Maspin, a serine protease inhibitor related to the serpin family, can inhibit invasion and metastasis of malignancies. This study aimed to explore the roles of maspin expression in the tumorigenesis and progression of colorectal adenocarcinoma (CRA). MATERIALS AND METHODS: Maspin expression was examined on tissue microarrays containing CRAs (n = 119), adjacent adenoma (n = 22), adjacent non-cancerous mucosa (n = 118) and metastases (n = 67) by immunostaining. Microvessel density (MVD) was determined after labeling with anti-CD34 antibody using immunnostaining. The maspin expression was compared with clinicopathological parameters of the tumors, including expression of p53, Ki-67 and tenascin, MVD, and survival data. RESULTS: Maspin expression showed significant increase from colorectal non-cancerous mucosa to adenocarcinoma through adenoma (p < 0.05). Maspin expression correlated negatively with liver metastasis of CRA (p < 0.05), positively with tenascin expression (p < 0.05), but not withtumor size, depth of invasion, local invasion via vessels, lymph node metastasis, differentiation, expression of Ki-67 and p53 or MVD (p > 0.05). Maspin expression in the metastases of CRA was significantly consistent with their corresponding primary foci (p < 0.05). Kaplan-Meier analysis revealed no significant relationship between maspin expression and survival time of carcinoma patients (p > 0.05). CONCLUSION: Up-regulated maspin expression was involved in colorectal adenoma-adenocarcinoma sequence. Low maspin expression is closely linked to the liver metastasis of CRA possibly through degradation of the extracellular matrix-tenascin to enhance carcinoma cell mobility.
机译：背景：Maspin是一种与丝氨酸蛋白酶抑制剂家族有关的丝氨酸蛋白酶抑制剂，可抑制恶性肿瘤的侵袭和转移。这项研究旨在探讨maspin表达在结直肠腺癌（CRA）的发生和发展中的作用。材料与方法：通过免疫染色，在包含CRA（n = 119），相邻腺瘤（n = 22），相邻非癌性粘膜（n = 118）和转移灶（n = 67）的组织微阵列上检查了Maspin表达。使用免疫染色用抗CD34抗体标记后，确定微血管密度（MVD）。将maspin表达与肿瘤的临床病理参数进行比较，包括p53，Ki-67和腱生蛋白的表达，MVD和存活数据。结果：Maspin表达从大肠非癌性粘膜到腺癌直至腺瘤均显着增加（p <0.05）。 Maspin表达与CRA肝转移呈负相关（p <0.05），与腱生蛋白表达呈正相关（p <0.05），但与肿瘤大小，浸润深度，血管局部浸润，淋巴结转移，分化，Ki-67表达无关p53或MVD（p> 0.05）。 Maspin在CRA转移灶中的表达与其相应的原发灶显着一致（p <0.05）。 Kaplan-Meier分析显示，maspin表达与癌症患者的生存时间之间无显着相关性（p> 0.05）。结论：maspin表达上调与大肠腺瘤-腺癌序列有关。 Maspin的低表达可能与CRA的肝转移密切相关，可能是通过细胞外基质-肌腱蛋白的降解来增强癌细胞的移动性。

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