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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Telomere length and telomerase activity in extra-abdominal desmoid tumors.
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Telomere length and telomerase activity in extra-abdominal desmoid tumors.

机译：腹外类胶质瘤的端粒长度和端粒酶活性。

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摘要

The telomere biology of extra-abdominal desmoids was investigated. In 12 specimens, telomere length was assessed by Southern-blot analysis and telomerase activity was measured using a PCR-based TRAP assay. There was a significant correlation between telomere length and tumor size, with telomeres being shorter with increasing tumor size (p = 0.049), and between telomere length and PCNA-positive cell rate, with telomere shortening with increased positive cell rate (p = 0.017). There was a significant correlation between telomerase activity and age at surgery, with increased activity with younger age (p = 0.015). Telomere length increased with recurrence, but telomerase activity decreased, and rate of PCNA-positive cells became lower, whenever the tumors were recurrent. Decreasing telomere length correlated with tumor size, probably due to increased duration of proliferation in the tumor, and tumor aggressiveness. Recurrent case results may be due to a lower rate of cell division and the presence of telomerase activity.
机译：研究了腹部外胶体的端粒生物学。在12个标本中，端粒长度通过Southern印迹分析进行了评估，端粒酶活性使用基于PCR的TRAP分析进行了测量。端粒长度和肿瘤大小之间存在显着相关性，端粒长度随着肿瘤大小的增加而变短（p = 0.049），端粒长度和PCNA阳性细胞率之间，端粒长度随着阳性细胞率的增加而缩短（p = 0.017） 。端粒酶活性与手术年龄之间存在显着相关性，且随着年龄的增长，活性增加（p = 0.015）。每当肿瘤复发时，端粒长度随复发而增加，但端粒酶活性降低，且PCNA阳性细胞率降低。端粒长度的减少与肿瘤的大小有关，这可能归因于肿瘤中增殖时间的延长和肿瘤的侵袭性。复发病例的结果可能是由于细胞分裂速率降低和端粒酶活性的存在。

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