9-(2-(phosphonomethoxy)ethyl)-2,6-diaminopurine (PMEDAP)--a potential drug against hematological malignancies--induces apoptosis.

Otova B; Francova K; Franek F; Koutnik P; Votruba I; Holy A; Sladka M; Schramlova J

首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >9-(2-(phosphonomethoxy)ethyl)-2,6-diaminopurine (PMEDAP)--a potential drug against hematological malignancies--induces apoptosis.

【24h】

9-(2-(phosphonomethoxy)ethyl)-2,6-diaminopurine (PMEDAP)--a potential drug against hematological malignancies--induces apoptosis.

机译：9-（2-（膦酰基甲氧基）乙基）-2,6-二氨基嘌呤（PMEDAP）-一种可能对抗血液系统恶性肿瘤的药物-诱导细胞凋亡。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Antitumor activity of the acyclic nucleotide analogs PMEDAP, PMEA, and PMEG was studied on a model of a spontaneous T-cell lymphoma in inbred SD/cub rats. Significant therapeutic effects were recorded after a treatment with 16 daily doses of PMEDAP at 5 mg/kg applied to the vicinity of the growing lymphoma. Identical administration of PMEA, or PMEG at a daily dose of 0.1 mg/kg did not affect the survival of lymphoma-bearing animals compared with untreated controls. A decrease in the lymphoma weight during PMEDAP administration was accompanied by the suppression of mitotic activity in neoplastic cells and increased chromatin condensation as witnessed by karyological examinations. Electron-microscopy showed the morphology of apoptotic cells (shrunken cells with condensed chromatin, apoptotic bodies) in lymphoma cell suspensions. An increase of nuclear DNA fragmentation was found during PMEDAP administration compared with spontaneous DNA fragmentation of untreated control lymphomas. These results indicate that PMEDAP application induces apoptosis in in vivo growing lymphomas. The antitumor effect of PMEDAP lasts only during the administration of the drug. After its cessation progression of neoplasia was reestablished.

机译：在近交SD /小白鼠自发性T细胞淋巴瘤模型上研究了无环核苷酸类似物PMEDAP，PMEA和PMEG的抗肿瘤活性。在生长的淋巴瘤附近，以16 mg / d的PMEDAP每日剂量5 mg / kg进行治疗后，记录到明显的治疗效果。与未经治疗的对照组相比，以0.1 mg / kg的日剂量相同剂量的PMEA或PMEG给药不会影响带有淋巴瘤的动物的存活。通过核医学检查可以看出，PMEDAP给药期间淋巴瘤重量的减少伴随着肿瘤细胞中有丝分裂活性的抑制和染色质凝结的增加。电镜显示淋巴瘤细胞悬浮液中的凋亡细胞（染色质浓缩的收缩细胞，凋亡小体）的形态。与未治疗的对照淋巴瘤的自发DNA片段相比，在PMEDAP给药期间发现了核DNA片段的增加。这些结果表明PMEDAP的应用诱导体内生长的淋巴瘤中的细胞凋亡。 PMEDAP的抗肿瘤作用仅在给药期间持续。停止发展后，肿瘤得以重建。

著录项

来源
《Anticancer Research: International Journal of Cancer Research and Treatment》 |1999年第4b期|共10页
作者
Otova B; Francova K; Franek F; Koutnik P; Votruba I; Holy A; Sladka M; Schramlova J;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Adenine; Antineoplastic Agents; Apoptosis; Lymphoma; T-Cell; 9-(2-phosphonylmethoxyethyl)-2; 6-diaminopurine; 腺嘌呤; 抗肿瘤药; 脱噬作用; 淋巴瘤; T细胞;

机译：Adenine;Antineoplastic Agents;Apoptosis;Lymphoma;T-Cell;9-(2-phosphonylmethoxyethyl)-2;6-diaminopurine;腺嘌呤;抗肿瘤药;脱噬作用;淋巴瘤;T细胞;

相似文献

外文文献
中文文献
专利

1. 9-(2-(phosphonomethoxy)ethyl)-2,6-diaminopurine (PMEDAP)--a potential drug against hematological malignancies--induces apoptosis. [J] . Otova B, Francova K, Franek F, Anticancer Research: International Journal of Cancer Research and Treatment . 1999,第4B期

机译：9-（2-（膦酰基甲氧基）乙基）-2,6-二氨基嘌呤（PMEDAP）-一种可能对抗血液系统恶性肿瘤的药物-诱导细胞凋亡。
2. Intramolecular p_p stacking interactions in aqueous solution in mixed-ligand copper(II) complexes formed by heteroaromatic amines and the nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]-2-aminopurine (PME2AP), an isomer of the antivirally active 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) [J] . Alfonso Ferna＇ndez-Botello, Anton_＇n Holy, Virtudes Moreno, Inorganica Chimica Acta . 2009,第3期

机译：杂芳族胺与核苷酸类似物9- [2-（膦氧基甲氧基）乙基] -2-氨基嘌呤（PME2AP）形成的混合配体铜（II）配合物在水溶液中的分子内p_p堆积相互作用。 [2-（膦酰基甲氧基）乙基]腺嘌呤（PMEA）
3. Nickel(II), Copper(II) and Zinc(II) Complexes of 9-[2- (Phosphonomethoxy)ethyl]-8-azaadenine (9,8aPMEA),the 8-Aza Derivative of the Antiviral Nucleotide Analogue 9-[2-(Phosphonomethoxy)ethyl] adenine (PMEA). Quantification of Four Isomeric Species in Aqueous Solution [J] . Raquel B.Gómez-Coca, AntonínHoly, Rosario A.Vilaplana, Bioinorganic chemistry and applications . 2004,第3a4期

机译：抗病毒核苷酸类似物9- [2]的8-氮杂衍生物9- [2-（膦甲氧基）乙基] -8-氮杂腺嘌呤（9,8aPMEA）的镍（II），铜（II）和锌（II）配合物-（膦甲氧基）乙基]腺嘌呤（PMEA）。水溶液中四种异构体的定量
4. Synthesis and Characterization of Luminescent Rod-Coil Poly2,7-(9,9- dihexylfluorene) - block-poly(2-(Dimethylamino) ethyl methacrylate) by Atom Transfer Radical Polymerization [C] . Yang-Yen Yu, Wen-Chen Chien, Chia-Liang Tsai International Conference on Multifunctional Materials and Structures . 2008

机译：发光杆线圈聚合物的合成与表征2,7-（9,9,9,9,9,9-二甲基氟烯） - 通过原子转移自由基聚合反应 - 聚（2-（二甲基氨基）甲基丙烯酸乙酯）
5. Activation by 9-(R)-2-(Phosphonomethoxy)PropylAdenine of Chemokine (RANTES Macrophage Inflammatory Protein 1α) and Cytokine (Tumor Necrosis Factor Alpha Interleukin-10 IL-10 IL-1β) Production [O] . Zdenĕk Zídek, Daniela Franková, Antonín Holý 2001

机译：被9-（R）-2-（膦甲氧基）丙基腺嘌呤激活趋化因子（RANTES巨噬细胞炎性蛋白1α）和细胞因子（肿瘤坏死因子α白介素10 IL-10IL-1β）的产生
6. Nickel(II), Copper(II) and Zinc(II) Complexes of 9-[2- (Phosphonomethoxy)ethyl]-8-azaadenine (9,8aPMEA), the 8-Aza Derivative of the Antiviral Nucleotide Analogue 9-[2-(Phosphonomethoxy)ethyl] adenine (PMEA). Quantification of Four Isomeric Species in Aqueous Solution [O] . Gómez-Coca, Raquel B., Holý, Antonín, Vilaplana, Rosario A., 2004

机译：9- [2-（Phosphoomethoxymethoxy）ethyl] -8-azaadenine（9,8aPMEA）的镍（II），铜（II）和锌（II）配合物，抗病毒核苷酸类似物9- [2-（膦甲氧基）乙基]腺嘌呤（PMEA）的8-氮杂衍生物。水溶液中四种异构体的定量

9-(2-(phosphonomethoxy)ethyl)-2,6-diaminopurine (PMEDAP)--a potential drug against hematological malignancies--induces apoptosis.

摘要

著录项

相似文献

相关主题

期刊订阅