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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Elevated serum 8-OHdG is associated with poor prognosis in epithelial ovarian cancer.
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Elevated serum 8-OHdG is associated with poor prognosis in epithelial ovarian cancer.

机译：血清8-OHdG升高与上皮性卵巢癌预后不良有关。

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摘要

BACKGROUND: 8-Hydroxydeoxyguanosine (8-OHdG) is a marker of oxidative stress in DNA. This study was undertaken to reveal whether serum 8-OHdG could be a prognostic factor in epithelial ovarian carcinoma (EOC). PATIENTS AND METHODS: Preoperative serum 8-OHdG levels were examined by enzyme-linked immunosorbent assay in 84 stage I-IV EOC patients. Immunohistochemical (IHC) 8-OHdG expression was determined in 78 of these patients. RESULTS: Strong 8-OHdG immunostaining predicted poor survival. High serum 8-OHdG (>140 pg/ml) was associated with poor ovarian cancer-specific survival (p<0.05) in patients with grade 1-2 EOC (p<0.05), but was not observed among the grade 3 patients. High 8-OHdG levels both in the serum and in the tumour tissue was associated with traditional factors of poor prognosis and serous histology. CONCLUSION: Both serum and IHC 8-OHdG assessment may serve as prognostic tools in EOC and the role of oxidative stress as a carcinogenic factor in ovarian cancer pathogenesis is also suggested.
机译：背景：8-羟基脱氧鸟苷（8-OHdG）是DNA中氧化应激的标志物。进行这项研究以揭示血清8-OHdG是否可能是上皮性卵巢癌（EOC）的预后因素。患者和方法：通过酶联免疫吸附法检测了84例I-IV期EOC患者的术前血清8-OHdG水平。在其中78例患者中确定了免疫组织化学（IHC）8-OHdG表达。结果：强的8-OHdG免疫染色预示了不良的存活率。 1-2级EOC的患者中高血清8-OHdG（> 140 pg / ml）与较差的卵巢癌特异性存活率（p <0.05）相关，但在3级患者中未观察到。血清和肿瘤组织中高的8-OHdG水平与不良预后和浆液组织学的传统因素有关。结论：血清和IHC 8-OHdG评估均可以作为EOC的预后工具，并且还建议氧化应激作为卵巢癌发病机理中的致癌因子。

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