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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Effect of BMP4 on the Growth and Clonogenicity of Human Leukemia and Lymphoma Cells.
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Effect of BMP4 on the Growth and Clonogenicity of Human Leukemia and Lymphoma Cells.

机译：BMP4对人白血病和淋巴瘤细胞生长和克隆形成的影响。

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摘要

Bone morphogenetic protein 4 (BMP4) signaling is involved in the maintenance of hematopoietic stem cells. However, the effects of BMP4 on leukemia and lymphoma cells are unknown.The effects of recombinant BMP4 on the in vitro growth of 12 leukemia and lymphoma cell lines were examined.BMP4 treatment promoted the short-term growth of three cell lines and suppressed the growth of one. Induction of differentiation was not observed. BMP4 treatment suppressed the clonogenicity of four out of the six examined cell lines. BMP4 treatment promoted the growth of Jurkat cells but suppressed their ability to form colonies. BMP4 treatment up-regulated the phosphorylation of SMAD1/5/8 complex, indicating that BMP4 mediated signal transduction in the cells.BMP4 suppressed the clonogenicity of selected leukemia and lymphoma cell lines. The regulation of BMP4 signaling may be a useful therapeutic approach for leukemia and lymphoma, if appropriate cases are selected.
机译：骨形态发生蛋白4（BMP4）信号传导与造血干细胞的维持有关。然而，BMP4对白血病和淋巴瘤细胞的作用尚不清楚，研究了重组BMP4对12种白血病和淋巴瘤细胞系体外生长的影响，BMP4处理促进了三种细胞系的短期生长并抑制了其生长。一。未观察到分化诱导。 BMP4处理抑制了所检查的六种细胞系中四种的克隆形成性。 BMP4处理促进了Jurkat细胞的生长，但抑制了它们形成菌落的能力。 BMP4处理上调了SMAD1 / 5/8复合物的磷酸化，表明BMP4介导了细胞内的信号转导.BMP4抑制了所选白血病和淋巴瘤细胞系的克隆形成性。如果选择适当的病例，BMP4信号的调节可能是白血病和淋巴瘤的有用治疗方法。

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