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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >The joint effect of hOGG1 single nucleotide polymorphism and betel quid chewing on oral cancer in Taiwan.
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The joint effect of hOGG1 single nucleotide polymorphism and betel quid chewing on oral cancer in Taiwan.

机译：hOGG1单核苷酸多态性与槟榔咀嚼对台湾口腔癌的联合作用。

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摘要

AIM: To evaluate the association and interaction among hOGG1 genotypic polymorphism, betel quid chewing status and oral cancer risk in Taiwan. MATERIALS AND METHODS: The well-known polymorphic variants of hOGG1, codon 326, were analyzed in association with oral cancer susceptibility, and discussed regarding its joint effect with individual habits on oral cancer susceptibility. In total, 620 patients with oral cancer and 620 healthy controls recruited from the China Medical Hospital were analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). RESULTS: The hOGG1 codon 326 genotypes were differently distributed between the oral cancer and control groups (p=0.0266) and the C allele of hOGG1 codon 326 was significantly (p=0.0046) more frequently found in cancer patients than in controls. We further analyzed the joint effects of gene variants and habits on oral cancer risk and found an interaction between hOGG1 codon 326 genotype and betel quid chewing status. The association of the C allele for hOGG1 codon 326 with oral cancer risk was found to be significant only in the betel quid chewer group (p=0.0149), not in the non-chewer group (p=0.8028). CONCLUSION: Our results provide evidence that the C allele of hOGG1 codon 326 may have a joint effect with betel quid chewing on the development of oral cancer.
机译：目的：评估台湾hOGG1基因型多态性，槟榔咀嚼状态和口腔癌风险之间的关联和相互作用。材料与方法：结合口腔癌易感性，分析了hOGG1的众所周知的多态性变体326号密码子，并讨论了其与个体习惯对口腔癌易感性的联合作用。通过聚合酶链反应和限制性片段长度多态性（PCR-RFLP）分析了从中国医科医院招募的620名口腔癌患者和620名健康对照。结果：hOGG1密码子326基因型在口腔癌和对照组之间的分布不同（p = 0.0266），hOGG1密码子326的C等位基因在癌症患者中的频率明显高于对照组（p = 0.0046）。我们进一步分析了基因变异和习惯对口腔癌风险的联合影响，发现hOGG1密码子326基因型与槟榔咀嚼状态之间存在相互作用。发现hOGG1密码子326的C等位基因与口腔癌风险的相关性仅在槟榔咀嚼组（p = 0.0149）中显着，而在非咀嚼组中则不显着（p = 0.8028）。结论：我们的结果提供了证据，表明hOGG1密码子326的C等位基因可能与咀嚼槟榔对口腔癌的发展有共同作用。

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