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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Hepatic arterial infusion in the treatment of liver metastases with PEG liposomes in combination with degradable starch microspheres (DSM) increases tumor 5-FU concentration. an animal study in CC-531 liver tumor-bearing rats.
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Hepatic arterial infusion in the treatment of liver metastases with PEG liposomes in combination with degradable starch microspheres (DSM) increases tumor 5-FU concentration. an animal study in CC-531 liver tumor-bearing rats.

机译：用PEG脂质体与可降解淀粉微球（DSM）组合治疗肝转移的肝动脉输注增加了肿瘤5-FU的浓度。 CC-531肝肿瘤大鼠的动物实验。

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摘要

The regional application of cytostatics in liver metastases leads to increased concentrations in the tumor tissue. The effect of flow retardation by temporary occlusion and drug targeting with liposome encapsulation (PEG liposomes) on tumor 5-fluorouracil (5-FU) concentrations was investigated. MATERIALS AND METHODS: Tumor-bearing rats were submitted to i.v. or intraarterial (i.a.) therapy with liposome-encapsulated or non-encapsulated 5-FU. The i.a. groups were additionally treated with or without Spherex(R) degradable starch microspheres (DSM). The tumor 5-FU concentrations were determined by high-performance liquid chromatography (HPLC) as area under the curve (AUC). RESULTS: A comparison with i.v. in administered 5-FU yielded the following increases tumor concentrations: 5-FU-PEG liposomes i.v. 27-fold, 5-FU i.a. 19-fold, 5-FU i.a. + DSM 1760-fold, 5-FU-PEG liposomes i.a. 110-fold, 5-FU-PEG liposomes i.a. + DSM 7665-fold. CONCLUSION: Liver intratumoral 5-FU concentration increases to >7,500 times that following i.v. administration by a combination of regional administration via the hepatic artery with temporary embolization by DSM and drug targeting by liposome-encapsulated 5-FU.
机译：细胞抑制剂在肝转移中的局部应用导致肿瘤组织中浓度增加。研究了通过暂时闭塞和脂质体包封（PEG脂质体）靶向药物对血流阻滞对肿瘤5-氟尿嘧啶（5-FU）浓度的影响。材料与方法：将荷瘤大鼠送入静脉注射。脂质体包裹或未包裹的5-FU进行动脉内或动脉内（i.a.）治疗。 i.a.各组另外用或不使用可降解淀粉微球（DSM）处理。通过高效液相色谱法（HPLC）将肿瘤5-FU浓度确定为曲线下面积（AUC）。结果：与i.v.的比较在施用的5-FU中，β-内啡肽产生以下增加的肿瘤浓度：5-FU-PEG脂质体。 27折5-FU i.a. 19折5-FU i.a. + DSM 1760倍5-FU-PEG脂质体110倍5-FU-PEG脂质体+ DSM 7665倍。结论：肝内5-FU的浓度增加到静脉注射后的> 7,500倍。通过肝动脉局部给药与DSM临时栓塞和脂质体包裹的5-FU靶向药物相结合的方法进行给药。

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