Structure of the human filamin A actin-binding domain

Salla Ruskamo; Jari Ylanne

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Structure of the human filamin A actin-binding domain

机译：人类的细丝蛋白actin-binding的结构域

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摘要

Filamin A (FLNa) is a large dimeric protein that binds to actin filaments via its actin-binding domain (ABD). The crystal structure of this domain was solved at 3.2 A resolution. The domain adopts a closed conformation typical of other ABDs, but also forms a dimer both in crystallization conditions and in solution. The structure shows the localization of the residues mutated in patients with periventricular nodular heterotopia or otopalatodigital syndrome. Structural analysis predicts that mutations in both types of disorder may affect actin binding.

机译：细丝蛋白(FLNa)是一个大型蛋白质二聚的通过其actin-binding结合肌动蛋白丝域(ABD)。域是3.2一项决议来解决。采用一个封闭的构象的典型abd,但也形成二聚体结晶条件和解决方案。结构显示了残留的本地化突变患者的室周的结节异位或otopalatodigital综合症。结构分析预测,突变这两种类型的障碍可能影响肌动蛋白绑定。

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《Acta crystallographica.Section D. Biological crystallography》 |2009年第11期|1217-1221|共5页
作者
Salla Ruskamo; Jari Ylanne;
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作者单位

The Department of Biological and Environmental Science, PO Box 35, University of Jyvaskyla, FIN-40014 Jyvaskyla, Finland;

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原文格式 PDF
正文语种英语
中图分类化学;
关键词
Dimers; Periventricular Nodular Heterotopia; crystal structureFilamin AMutationActin CytoskeletonFLNA geneDomain;

机译：二聚体,室旁结节性异位;晶体structureFilamin AMutationActin CytoskeletonFLNAgeneDomain;

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Structure of the human filamin A actin-binding domain

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