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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Effect of green tea extract on reactive oxygen species produced by neutrophils from cancer patients.
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Effect of green tea extract on reactive oxygen species produced by neutrophils from cancer patients.

机译：绿茶提取物对癌症患者中性粒细胞产生的活性氧的影响。

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摘要

Oxidative stress in cancer patients has been demonstrated to be partly mediated by neutrophils. Although it is reported that natural antioxidants, such as green tea extract, reduce oxidative stress, there is limited evidence of their effects in cancer patients. This study aimed to determine the effect of green tea extract on reactive oxygen species produced by neutrophils from cancer patients.Peripheral blood samples were obtained from eighteen patients with advanced cancer. Green tea extract was added to the blood samples with luminol on Mebiol gel, and luminol-dependent chemiluminescence was measured to monitor the production of reactive oxygen species from migrated neutrophils into the gel, at 37°C.Luminol-dependent chemiluminescence was significantly down-regulated in the presence of green tea extract in a concentration-dependent manner.These results indicate the antioxidant effect of green tea extract on reactive oxygen species produced by neutrophils, which may be effective in reducing oxidative stress in cancer patients.
机译：癌症患者的氧化应激已被证明部分由嗜中性粒细胞介导。尽管据报道，天然抗氧化剂，例如绿茶提取物，可以降低氧化应激，但在癌症患者中其作用的证据有限。本研究旨在确定绿茶提取物对癌症患者嗜中性粒细胞产生的活性氧的影响。从18例晚期癌症患者中获取外周血样本。将绿茶提取物与Lubiol在Mebiol凝胶上一起添加到血液样本中，并在37°C下测量Luminol依赖性化学发光以监测从迁移的中性粒细胞进入凝胶的活性氧种类的产生.Luminol依赖性化学发光显着降低-这些结果表明绿茶提取物对嗜中性粒细胞产生的活性氧具有抗氧化作用，可能有效降低癌症患者的氧化应激。

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