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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Determining the DUF55-domain structure of human thymocyte nuclear protein 1 from crystals partially twinned by tetartohedry
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Determining the DUF55-domain structure of human thymocyte nuclear protein 1 from crystals partially twinned by tetartohedry

机译：决定人类的DUF55-domain结构胸腺细胞核酸蛋白质1晶体部分由四分对称成双成对的

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摘要

Human thymocyte nuclear protein 1 contains a unique DUF55 domain consisting of 167 residues (55-221), but its cellular function remains unclear. Crystals of DUF55 belonged to the trigonal space group P3_1, but twinning caused the data to approach apparent 622 symmetry. Two data sets were collected to 2.3 A resolution. Statistical analysis confirmed that both data sets were partially twinned by tetartohedry. Tetartohedral twin fractions were estimated. After the structure had been determined, only one twofold axis of rotational pseudosymmetry was found in the crystal structure. Using the DALI program, a YTH domain, which is a potential RNA-binding domain from human YTH-domain-containing protein 2, was identified as having the most similar three-dimensional fold to that of DUF55. It is thus implied that DUF55 might be a potential RNA-related domain.
机译：人胸腺细胞的核蛋白质1包含了一个独特的167年残留DUF55域组成(55 - 221),但其细胞功能仍然存在不清楚。三方晶系的空间群P3_1,但造成的孪生数据接近622年明显对称。收集的数据集到2.3一项决议。统计分析证实,这两个数据集被四分对称部分成双成对的。Tetartohedral双胞胎分数估计。结构被确定后,只有一个双重的旋转轴心伪对称在晶体结构中找到。项目,从技术上说一个云天化领域,这是一个潜力从人类rna结合域YTH-domain-containing蛋白质2,被确认最相似的三维折叠DUF55。可能是一个潜在的RNA-related域。

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