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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Predictive factors for preoperative serum levels of sialy Lewis(x), sialyl Lewis(a) and sialyl Tn antigens in gastric cancer patients.
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Predictive factors for preoperative serum levels of sialy Lewis(x), sialyl Lewis(a) and sialyl Tn antigens in gastric cancer patients.

机译：胃癌患者术前血清唾液酸Lewis（x），唾液酸化Lewis（a）和唾液酸Tn抗原的血清水平的预测因素。

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摘要

Preoperative serum levels of sialyl Lewis(a) (CA19-9), sialyl Lewis(x) (SLX) and sialyl Tn (STN) antigens in 180 patients with gastric cancer were examined to establish predictive factors for serum levels of these antigens compared with carcinoembryonic antigen (CEA). The patients were divided into low and high antigen groups. Multivariate logistic regression analysis revealed the following independent predictive factors for high antigen levels [odds ratio]: liver metastasis for CA19-9 [4.40], SLX [9.90], STN [39.65] and CEA [5.14]; peritoneal dissemination for SLX [4.78] or STN [13.01]; venous invasion for CEA [3.56]; lymph node metastasis for CA19-9 [4.51]. In addition, high CA19-9 levels were independently related to lymph node metastasis in patients with stage I or II tumors. In conclusion, high serum levels of CA19-9, SLX and STN are associated with liver metastasis, while high serum levels of SLX and STN are associated with peritoneal dissemination. In addition, high serum CA19-9 levels may represent an independent predictor for lymph node metastasis.
机译：检查180例胃癌患者术前血清唾液酸Lewis（a）（CA19-9），唾液酸Lewis（x）（SLX）和唾液酸Tn（STN）抗原的水平，以建立与这些抗原相比血清抗原水平的预测因素癌胚抗原（CEA）。将患者分为低和高抗原组。多元logistic回归分析显示高抗原水平[几率]的以下独立预测因素：CA19-9 [4.40]，SLX [9.90]，STN [39.65]和CEA [5.14]的肝转移; SLX [4.78]或STN [13.01]的腹膜扩散; CEA的静脉侵袭[3.56]; CA19-9的淋巴结转移[4.51]。此外，I或II期肿瘤患者的高CA19-9水平与淋巴结转移独立相关。总之，高血清CA19-9，SLX和STN与肝转移有关，而高血清SLX和STN与腹膜扩散有关。此外，高血清CA19-9水平可能代表淋巴结转移的独立预测因子。

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