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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Continuous saline bladder irrigation after transurethral resection is a prophylactic treatment choice for non-muscle invasive bladder tumor.
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Continuous saline bladder irrigation after transurethral resection is a prophylactic treatment choice for non-muscle invasive bladder tumor.

机译：经尿道切除后连续生理盐水冲洗是非肌肉浸润性膀胱肿瘤的预防性治疗选择。

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摘要

BACKGROUND: Instillation of chemotherapy after transurethral resection (TUR) has been considered as an optimal treatment for non-muscle invasive bladder cancer (NMIBC). However, controversy remains regarding the role of chemotherapy instillation. We therefore evaluated the usefulness of continuous saline bladder irrigation (CSBI) after TUR. PATIENTS AND METHODS: Patients with intermediate risk NMIBC were treated by TUR followed by either CSBI (123 patients) or intravesical instillation of mitomycin C (115 patients). Recurrence-free rates were estimated using the Kaplan-Meier method. RESULTS: No significant differences were observed in the recurrence-free rate, period to first recurrence, nor in frequency of recurrence between the CSBI and intravesical chemotherapy groups. Tumor progression rate and local toxicities were significantly higher in the intravesical chemotherapy group. CONCLUSION: CSBI after TUR appears to be a prophylactic treatment choice for intermediate risk NMIBC patients, in terms of its equal prophylactic effect to intravesical chemotherapy with mitomycin C, and its safety and cost benefits.
机译：背景：经尿道切除术（TUR）后滴注化学疗法已被认为是非肌肉浸润性膀胱癌（NMIBC）的最佳治疗方法。但是，关于化学滴注的作用仍存在争议。因此，我们评估了TUR后进行连续盐水膀胱冲洗（CSBI）的有用性。病人和方法：中度危重NMIBC患者接受TUR治疗，然后CSBI治疗（123例）或丝裂霉素C膀胱灌注（115例）。使用Kaplan-Meier方法估算无复发率。结果：CSBI组和膀胱内化疗组之间的无复发率，首次复发时间以及复发频率均无显着差异。膀胱内化疗组的肿瘤进展率和局部毒性显着更高。结论：就其与丝裂霉素C膀胱内化疗的预防效果相同，安全性和成本效益而言，TUR后CSBI似乎是中危NMIBC患者的预防性治疗选择。

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