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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Antiproliferative effects of rapamycin and celecoxib in angiosarcoma cell lines.
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Antiproliferative effects of rapamycin and celecoxib in angiosarcoma cell lines.

机译：雷帕霉素和塞来昔布在血管肉瘤细胞系中的抗增殖作用。

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BACKGROUND/AIM: Beyond their primary field of application some well-established drugs exhibit antitumour effects in a variety of cancers. The aim of this study was to investigate the effects of the COX2 inhibitor celecoxib and the mTOR antagonist rapamycin on angiosarcoma cell lines. MATERIALS AND METHODS: Cell proliferation was measured in ASM, ISOS 1 and ISO HAS angiosarcoma cell lines with the BrdU assay. RESULTS: In all angiosarcoma cell lines, celecoxib as well as rapamycin inhibited cell growth in a dose-dependent manner. In ASM and ISOS 1, but not in ISO HAS angiosarcoma cells, additive growth inhibitory effects were detected by combining both agents. CONCLUSION: Our results indicate that angiosarcoma cell proliferation can be inhibited by subtoxic doses of rapamycin and celecoxib. Due to their direct and stroma-mediated anticancer activities, mTOR antagonists and COX2 inhibitors represent very promising drugs in the palliative treatment of angiosarcoma.
机译：背景/目的：除了其主要应用领域外，一些成熟的药物还对多种癌症表现出抗肿瘤作用。这项研究的目的是研究COX2抑制剂塞来昔布和mTOR拮抗剂雷帕霉素对血管肉瘤细胞系的影响。材料与方法：用BrdU测定法在ASM，ISOS 1和ISO HAS血管肉瘤细胞系中测量细胞增殖。结果：在所有血管肉瘤细胞系中，塞来昔布和雷帕霉素均以剂量依赖性方式抑制细胞生长。在ASM和ISOS 1中，但在ISO HAS血管肉瘤细胞中未发现，通过将两种药物结合使用可检测到加性生长抑制作用。结论：我们的结果表明，亚毒性剂量的雷帕霉素和塞来昔布可以抑制血管肉瘤细胞的增殖。由于其直接的和基质介导的抗癌活性，mTOR拮抗剂和COX2抑制剂在血管肉瘤的姑息治疗中代表了非常有前途的药物。

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