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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Short-term and low-dose prednisolone administration reduces aromatase inhibitor-induced arthralgia in patients with breast cancer.
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Short-term and low-dose prednisolone administration reduces aromatase inhibitor-induced arthralgia in patients with breast cancer.

机译：短期和小剂量泼尼松龙的给药减少了乳腺癌患者芳香化酶抑制剂引起的关节痛。

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摘要

Aromatase inhibitors (AIs) are important therapeutic drugs for postmenopausal women with hormone receptor-positive breast cancer. However, adverse effects of AIs such as arthralgia have been extensively reported. We performed a joint prospective, multi-institutional investigation to find out whether a low-dose and short-term prednisolone is effective against AI-induced arthralgia in 27 patients with breast cancer. Patients were administered 5 mg of oral prednisolone once a day in the morning for only one week. Patients were then asked to answer a questionnaire about joint pain symptoms at one week, one month and two months after the beginning of prednisolone use. Joint pain symptoms improved in 67% of patients immediately after prednisolone use, with 63% still reporting analgesic effect at one month, and 52% at two months after beginning internal use of prednisolone. At one week, one month and two months after the use of prednisolone, 30%, 30% and 26% of patients reported improved daily life, respectively. Our results suggest that prednisolone could substitute non-steroidal anti-inflammatory drugs, acetoaminophen or cyclooxygenase-2 inhibitors in patients with AI-induced arthralgia.
机译：芳香酶抑制剂（AIs）是绝经后激素受体阳性乳腺癌女性的重要治疗药物。然而，已经广泛报道了诸如关节痛之类的AI的不良作用。我们进行了一项前瞻性，多机构联合调查，以了解低剂量和短期泼尼松龙对27例乳腺癌患者对AI引起的关节痛是否有效。每天一次给患者服用5 mg口服泼尼松龙，仅一周。然后要求患者在开始使用泼尼松龙后的一周，一个月和两个月回答有关关节痛症状的问卷。泼尼松龙使用后立即有67％的患者出现关节疼痛症状，其中63％的患者在一个月后仍报告镇痛作用，而在开始内部使用泼尼松龙后两个月仍有52％的镇痛作用。泼尼松龙使用后第一个星期，一个月和两个月，分别有30％，30％和26％的患者报告了日常生活的改善。我们的结果表明，强的松龙可以替代AI引起的关节痛的患者使用非甾体抗炎药，醋氨酚或环氧合酶2抑制剂。

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