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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Isomorph expression of BAG-1 gene, ER and PR in endometrial cancer.
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Isomorph expression of BAG-1 gene, ER and PR in endometrial cancer.

机译：BAG-1基因，ER和PR在子宫内膜癌中的同型表达。

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BACKGROUND: BAG-1 isomorphs are regulating proteins with antiapoptotic action in endometrium. ERa and PRA isomorphs seem to have an important role in endometrial cancer. PATIENTS AND METHODS: We investigated the expression of BAG-1, ERa and PRA isomorphs in endometrioid adenocarcinoma and we correlated them with clinicopathological findings of the tumor. Fresh endometrial tissues were obtained from 33 patients with endometrial carcinoma and 191 paraffin-embedded tissues were analyzed by real-time PCR and immunochemistry for BAG-1, ER and PR. RESULTS: BAG-1 protein is expressed in both nucleus and cytoplasm. Grade 3 tumors were considered to have the highest intensity. Only 4 out of 79 samples showed intense expression of ERa, while 37 samples out of 72 samples strongly expressed PRA. CONCLUSION: BAG-1 nuclear isomorph appeared more frequently in grade 2 tumors than in grade 1 and 3 tumors, and the cytoplasmatic isomorph was expressed more strongly than the nuclear one.
机译：背景：BAG-1同种型调节子宫内膜具有抗凋亡作用的蛋白质。 ERa和PRA同种型似乎在子宫内膜癌中具有重要作用。患者与方法：我们研究了子宫内膜样腺癌中BAG-1，ERα和PRA亚型的表达，并将其与肿瘤的临床病理结果相关联。从33例子宫内膜癌患者中获得新鲜的子宫内膜组织，并通过实时PCR和免疫化学法对191例石蜡包埋的组织进行BAG-1，ER和PR的分析。结果：BAG-1蛋白在细胞核和细胞质中均表达。 3级肿瘤被认为具有最高强度。 79个样本中只有4个显示出ERa的强烈表达，而72个样本中有37个样本强烈表达了PRA。结论：BAG-1核同型物在2级肿瘤中比在1级和3级肿瘤中更常见，并且胞质同工型比核中更强烈地表达。

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