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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Percutaneous US-guided radiofrequency ablation of hepatocellular carcinomas: results in 15 patients.
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Percutaneous US-guided radiofrequency ablation of hepatocellular carcinomas: results in 15 patients.

机译：经皮超声引导的肝细胞癌射频消融：纳入15例患者。

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BACKGROUND: The majority of patients with hepatocellular carcinoma (HCC) cannot undergo surgery because of multifocality, location or advanced cirrhosis. Our experience with percutaneous radiofrequency ablation for treatment of patients suffering from unresectable hepatocellular carcinoma is described here. PATIENTS AND METHODS: Fifteen patients (ten men and five women) with eighteen primary hepatocellular tumors underwent percutaneous radiofrequency ablation. The mean diameter of the HCCs was 32 mm (ranging from 15 mm to 62 mm). The patients were treated under ultrasound guidance using either a 18-gauge internally cooled electrode or a 14-gauge electrode with four expandable hooks. RESULTS: Complete necrosis was achieved in 15 lesions after one session of RF ablation. The persistence of a small portion of viable tissue was seen in two lesions. One lesion was not evaluable. After a mean follow-up period of 9.2 months (range 3-24 months), eleven patients (76%) showed no sign of local or distant recurrence, one patient developed a new lesion and one of two patients with persistence of viable tissue obtained a complete necrosis after the injection of percutaneous ethanol. Moreover, a major complication (intraperitoneal bleeding requiring surgical treatment) and three minor complications (1 pleuric effusion and 2 perihepatic fluid collections that resolved spontaneously) were observed. CONCLUSION: RF ablation is a simple, well-tolerated and effective procedure for the treatment of unresectable hepatocellular carcinomas.
机译：背景：大多数肝细胞癌（HCC）患者由于多灶性，部位性或晚期肝硬化而无法接受手术。本文介绍了我们在经皮射频消融治疗无法切除的肝细胞癌患者中的经验。患者与方法：15例（18名男性和5名女性）患有18例原发性肝细胞肿瘤的患者接受了经皮射频消融术。 HCC的平均直径为32毫米（范围从15毫米到62毫米）。使用18规格的内部冷却电极或14规格的电极（带有四个可扩展的钩子）在超声引导下对患者进行治疗。结果：射频消融治疗后15个病变完全坏死。在两个病变中可见一小部分存活组织的残留。一个病变无法评估。平均随访9.2个月（3-24个月）后，有11例患者（76％）未显示出局部或远处复发的迹象，其中1例患者出现了新的病变，而2例患者中有1例患者存活组织持续存在经皮乙醇注射后完全坏死。此外，观察到主要并发症（需要手术治疗的腹膜内出血）和三个较小的并发症（1个胸膜积液和2个自发分解的肝周液集合）。结论：射频消融术是一种简单，耐受良好且有效的治疗不可切除的肝细胞癌的方法。

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